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FLASH GENE
Symbol CXCR1 contributors: mct - updated : 03-06-2019
HGNC name chemokine (C-X-C motif) receptor 1
HGNC id 6026
Location 2q35      Physical location : 219.027.569 - 219.031.716
Synonym name
  • CXC chemokine receptor 1
  • interleukin 8 receptor, alpha
  • CD181 antigen
  • high affinity interleukin-8 receptor A
  • Synonym symbol(s) IL8R2, CMKAR1, CD128, IL8R1, CMKAR1, IL8RBA, CDw128a, C-C CKR-1, C-C-CKR-1, IL8RA, CKR-1, CD181
    DNA
    TYPE functioning gene
    STRUCTURE 4.15 kb     2 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2502 39.7 350 - 2018 30384436
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
     thyroid    
    Lymphoid/Immunespleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil Homo sapiens
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • inhibiting embryonic oligodendrocyte precursor migration in developing spinal cord
  • might be involved in the recruitment of polymorphonuclear leukocytes to the glomerular tuft, which could be targeted by CXCR1-blocking agents
  • CXCR1 and CXCR2 expression plays a critical role in regulating multiple biological activities in human microvascular endothelial cells
  • CXCR1 and CXCR2 are novel mechanosensors mediating laminar shear-stress-induced endothelial cell (EC) migration
  • CXCR1 and CXCR2 couple to distinct GRK isoforms to mediate and regulate inflammatory responses
  • is a class-A, rhodopsin-like G-protein-coupled receptor (GPCR), the largest class of integral membrane proteins responsible for cellular signal transduction and targeted as drug receptors
  • IL8 and its receptor CXCR1 are key mediators in combating infection and have also been implicated in the pathophysiology of various diseases including chronic obstructive pulmonary disease (COPD) and cancer
  • CXCR1 is required for packaging of enzymes into exosomes that mediate their hepatocyte proliferative effect.
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding CXCL8 (its ligand)
  • CXCR1 predominantly couples to GRK2
  • is one of two high-affinity receptors for the CXC chemokine interleukin-8 (IL8), a major mediator of immune and inflammatory responses implicated in many disorders, including tumour growth
  • IL8 plays a major role in neutrophil chemotaxis caused by alveolar macrophage-derived conditioned media, and this is most effectively inhibited by dual antagonism of CXCR1 and CXCR2
  • novel functional network of ELANE, secretases, and F2RL1 that regulate CXCR1 expression on neutrophils
  • IL8/CXCR1 axis is associated with the cancer stem cell (CSC)-like properties of pancratic cancer cells and prognosis in human pancreatic cancer
  • IL8 function involves binding two distinct CXCR1 sites - the N-terminal domain (Site-I) and the extracellular/transmembrane domain (Site-II)
  • IL8, a potent neutrophil-activating chemokine, exerts its function by activating the CXCR1 receptor that belongs to class A G protein-coupled receptors (GPCRs)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    on infiltrating inflammatory cells as well as on intrinsic renal cells (arterial smooth muscle cells, endothelial cells of peritubular capillaries)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    novel therapeutic target for gastric cancer
    ANIMAL & CELL MODELS