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FLASH GENE
Symbol CXCL6 contributors: - updated : 30-04-2005
HGNC name chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
HGNC id 10643
Location 4q21      Physical location : 74.702.272 - 74.704.476
Synonym name
  • small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2)
  • granulocyte chemotactic protein 2
    • Synonym symbol(s) GCP2, SCYB6
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 2.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - IL8 - CXCL1 / PPBP / PF4 - CXCL5 / CXCL6 - CXCL2 / CXCL3 - CXCL11 - CXCL10 - CXCL9 - qter
    Authors O'Donovanet al. (99)
    Physical map
    FLJ38991 4q21.1 hypothetical protein FLJ38991 ANKRD17 4q13.3 ankyrin repeat domain 17 HMGA1L2 4q21.1 high mobility group AT-hook 1-like 2 ALB 4q11-q13 albumin AFP 4q11-q13 alpha-fetoprotein AFM 4q11-q13 afamin RASSF6 4q21.21 Ras association (RalGDS/AF-6) domain family 6 IL8 4q13-q21 interleukin 8 CXCL6 4q21 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) PF4V1 4q13-q21 platelet factor 4 variant 1 CXCL1 4q21 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) CXCL1P 4q21.21 chemokine (C-X-C motif) ligand 1 pseudogene PF4 4q13-q21 platelet factor 4 (chemokine (C-X-C motif) ligand 4) PPBP 4q12-q13 pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) CXCL5 4q13-q21 chemokine (C-X-C motif) ligand 5 CXCL3 4q21 chemokine (C-X-C motif) ligand 3 SPBPBP 4q21.21 DNA-binding protein amplifying expression of surfactant protein B CXCL2 4q21 chemokine (C-X-C motif) ligand 2 LOC255324 4q21.21 similar to ALGV3072 EREG 4q25-q26 epiregulin AREG 4q13-q21 amphiregulin (schwannoma-derived growth factor)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Scyb6
    Homologene
    FAMILY intercrine alpha family
    CATEGORY immunity/defense , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION playing a chemotactic role for neutrophil granulocytes
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by IL-1alpha stimulation in corneal keratocytes
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS