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FLASH GENE

Symbol

CXCL5

contributors: mct - updated : 18-03-2008

HGNC name	chemokine (C-X-C motif) ligand 5
HGNC id	10642

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q13.3      Physical location : 74.861.359 - 74.864.416
Genatlas name	see IMC2@
Synonym name	neutrophil activating peptide 2
	small inducible cytokine subfamily B (Cys-X-Cys), member 5
	epithelial-derived neutrophil-activating peptide 78
Synonym symbol(s)	NAP2, SCYB5, ENA-78

DNA

TYPE	functioning gene
STRUCTURE	3.06 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002994 4 - 2475 - 114 - Park (2007)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Homo sapiens Respiratory lung       highly Urinary bladder           kidney         Visual eye anterior segment cornea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage Homo sapiens Visual lens fibers

cell lineage	adipose tissue-derived stem cells
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

intercrine alpha family

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION	extracellular
text	both CXCL5 and CXCR2 were localized in the tunica intima and tunica adventitia of blood vessels in adipose tissue

basic FUNCTION	involved in neutrophil activation
	promote angiogenesis related to cancer
	exhibited chemoattractant and angiogenic properties (
	exerts chemoattraction through CXCR2

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

CXCL5/CXCR2 axis is likely responsible for the therapeutic effects via angiogenesis

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

IL-1alpha or TNF-alpha stimulation in corneal cells

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular atheroma   CXCL5 expression/secretion could contribute to adipose tissue-derived stem cells therapeutic potential by promoting angiogenesis in ischemic tissues

ANIMAL & CELL MODELS