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FLASH GENE
Symbol CXCL16 contributors: mct - updated : 12-10-2010
HGNC name chemokine (C-X-C motif) ligand 16
HGNC id 16642
Location 17p13.2      Physical location : 4.636.829 - 4.643.223
Synonym name
  • CXC chemokine ligand 16
  • scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
  • small inducible cytokine 16
  • transmembrane chemokine CXCL16
  • Synonym symbol(s) SRPSOX, CXCLG16, SCYB16, SRPSOX
    DNA
    TYPE functioning gene
    STRUCTURE 6.40 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC29671 17p13.3 hypothetical protein MGC29671 LOC124976 17p13.3 hypothetical protein LOC124976 MYBBP1A 17p13.3 MYB binding protein (P160) 1a FLJ90165 17p13.3 hypothetical protein FLJ90165 LOC124974 17p13.3 thioredoxin 1 pseudogene 4 FLJ42461 17p13.3 FLJ42461 protein ALOX15 17p13.1 arachidonate 15-lipoxygenase PELP1 17p13.3 arachidonate 15-lipoxygenase LOC390758 17 similar to 40S RIBOSOMAL PROTEIN S12 ARRB2 17p13 arrestin, beta 2 CXCL16 17p13 chemokine (C-X-C motif) ligand 16 LOC388322 17 similar to HSPC296 ZMYND15 17p13.3 zinc finger, MYND domain containing 15 TM4SF5 17p13.3 transmembrane 4 superfamily member 5 LOC284013 17p13.3 secretory protein LOC284013 LOC388323 17 similar to RIKEN cDNA C730027E14 PSMB6 17p13 proteasome (prosome, macropain) subunit, beta type, 6 PLD2 17p13.1 phospholipase D2 LOC284015 17p13.3 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit MINK 17p13 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit CHRNE 17p13.1 cholinergic receptor, nicotinic, epsilon polypeptide GP1BA 17pter-p12 glycoprotein Ib (platelet), alpha polypeptide SLC25A11 17p13.3 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 DKFZP566H073 17p13.3 DKFZP566H073 protein PFN1 17p13.3 profilin 1 ENO3 17pter-p12 enolase 3, (beta, muscle) SPAG7 17p13.2 sperm associated antigen 7 CAMTA2 17p13.3 calmodulin binding transcription activator 2 LOC388324 17 LOC388324 KIF1C 17p13 kinesin family member 1C FLJ10060 17p13.3 putative G-protein coupled receptor GPCR42 FLJ30726 17p13.3 hypothetical protein FLJ30726
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2344 29.5 273 - - 11060282
    5 - 1466 - 273 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunelymph node    
     spleen   highly
     thymus   highly
    Nervousbrainhindbrainmedulla oblongata  
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Cxcl16
    Homologene
    FAMILY
  • intercrine alpha (chemokine CxC) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text transmembrane protein, also a soluble form, type 2 membrane protein
    basic FUNCTION
  • scavenger receptor, binding, interacting and degrading oxidized LDL
  • playing an important role in atherosclerotic lesion formation
  • co-expressed with CXCR6 by first-trimester trophoblast cells and stimulate their proliferation and invasion in an autocrine/paracrine manner
  • functions, through CXCR6, as a novel chemotactic factor for prostate cancer cells
  • plays important roles in human extravillous cytotrophoblast invasion and placentation
  • involved in the accumulation of cellular cholesterol during atherosclerotic lesion development
  • may act as a novel angiogenic factor for HUVEC (umbilical vein endothelial cells) and EPHB2 is involved as an important signaling molecule to mediate its angiogenic effects
  • critical mediator of muscle regeneration, and it suppresses the development of fibrosi
  • may play a role in matrix remodeling and ultimately in the development of heart failure
  • transmembrane chemokine combining functions of a chemokine and a scavenger receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , immunity/defense , cellular trafficking transport
    text T cell trafficking, thymocyte development
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binding phosphatidyl serine
  • protein
  • binding oxidized lipoproteins
  • SND1 promotes angiogenesis by augmenting the production of angiogenin and CXCL16
  • P2RX7 activation induces the rapid shedding of CXCL16 and this process involves ADAM10
  • cell & other
  • binding NK cells and a subset of memory CD4 T cells
  • REGULATION
    induced by interferon gamma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in atherosclerotic lesions
    tumoral       gain of function
    is a common response of tumor cells to radiation, and they have important implications for the use of local radiotherapy in combination with immunotherapy
    tumoral     --over  
    in aggressive prostate cancer cells compared with the less aggressive tumor cells and benign cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS