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FLASH GENE
Symbol CXCL13 contributors: mct/npt/pgu - updated : 25-06-2010
HGNC name chemokine (C-X-C motif) ligand 13
HGNC id 10639
Location 4q21.1      Physical location : 78.432.906 - 78.532.986
Synonym name
  • chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
  • B-cell-homing chemokine (ligand for Burkitt's
  • small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)lymphoma receptor-1)
  • B-cell chemoattractant
  • CXC chemokine BLC
  • Synonym symbol(s) BLC, BCA1, ANGIE, BCA-1, SCYB13, BLR1L, ANGIE2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 100.08 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ASAHL 4q21.1 N-acylsphingosine amidohydrolase (acid ceramidase)-like FLJ10498 4q21.21 hypothetical protein FLJ10498 CXCL9 4q21.2 chemokine (C-X-C motif) ligand 9 CXCL10 4q21.2 chemokine (C-X-C motif) ligand 10 CXCL11 4q21.2 chemokine (C-X-C motif) ligand 11 ART3 4p15.1-p14 ADP-ribosyltransferase 3 NUP54 4q21.1 nucleoporin 54kDa SCARB2 4q21.1 scavenger receptor class B, member 2 GENX-3414 4q24-q25 genethonin 1 FLJ25770 4q21.22 hypothetical protein FLJ25770 ShrmL 4q21.22 Shroom-related protein LOC152825 4q21.22 similar to ribosomal protein L26 LOC345079 4q21.22 similar to RIKEN cDNA 5730467H21 FLJ10849 4q21.22 hypothetical protein FLJ10849 AF357530 4q21.1 thioredoxin 1 pseudogene 3 CCNI 4pter-qter cyclin I LOC339966 4q21.22 similar to Gene product with similarity to Ubiquitin binding enzyme CCNG2 4q21.22 cyclin G2 CXCL13 4q21 chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) CNOT6L 4q13.3 CCR4-NOT transcription complex, subunit 6-like MRPL1 4q21.1 mitochondrial ribosomal protein L1 LOC391670 4 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) FRAS1 4q21.21 Fraser syndrome 1 ANXA3 4q13-q22 annexin A3 LOC391671 4 similar to ribosomal protein S21; 40S ribosomal protein S21 BMP2K 4q21.23 BMP2 inducible kinase PAQR3 4q21.23 progestin and adipoQ receptor family member III
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1219 - 109 - 1998 9486651
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
     intestinelarge intestinecaecumappendix vermicular 
     liver   highly
     salivary gland    
     stomach    
    Lymphoid/Immunelymph node   highly
     spleen   highly
    Reproductivefemale systembreastmammary gland highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular  
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text lowly in spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Blc
    Homologene
    FAMILY
  • intercrine alpha (chemokine CxC) family
  • chemokine CXC subfamily
  • CATEGORY immunity/defense , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text soluble fraction
    basic FUNCTION
  • required for B1 cell homing, natural antibody production and body cavity immunity
  • chemotactive for B lymphocytes and activated T cell
  • playing an important role not only in the formation of normal gut associated lymphoid tissue but also in the generation of aberrant lymphoid tissue in inflammatory bowel disease
  • homeostatic chemokine for lymphocyte homing and positioning within follicles of secondary lymphoid tissues, acting through its cognate receptor, CXCR5
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS inflammation
    text
  • anti-pathogen response
  • cytosolic calcium ion concentration elevation
  • chemotactive for B lymphocytes
  • PATHWAY
    metabolism
    signaling signal transduction
  • cell to cell signaling
  • . CXCL13/CXCR5 signaling effect on shaping B-cell dynamics is an effective mechanism that enhances antigen encounter and BCR-triggered B-cell activation
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of CXCR5 (CXCL13-CXCR5 axis is significantly associated with prostate cancer progression)
  • cell & other
    REGULATION
    inhibited by by antibody against CXCR3 (BCA1 induced chemotaxis)
    transiently down-regulated within lymphoid tissues during immune responses by a mechanism controlled by the cytokine interferon-gamma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    with its receptor, CXCR5 in B-cell chronic lymphocytic leukemia
    tumoral     --over  
    in breast cancer, significantly elevated serum concentrations of CXCL13 in patients with metastatic disease
    Susceptibility to ulcerative colitis
    Variant & Polymorphism
    Candidate gene
    Marker
  • prognostic marker for oral squamous cell carcinoma development and progression
  • marker that appears to be helpful in clinically atypical cases of Lyme neuroborreliosis, and, in particular, in early stages of the disease when the B burgdorferi AI is (still) negative
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    might serve as a useful therapeutic target and/or diagnostic marker in this malignancy
    cancerhead and neck 
    potential therapeutic target to prevent oral squamous cell carcinoma bone invasion/osteolysis
    ANIMAL & CELL MODELS
    blc knock out mice