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FLASH GENE
Symbol CXCL10 contributors: mct - updated : 24-02-2010
HGNC name chemokine (C-X-C motif) ligand 10
HGNC id 10637
Location 4q21.1      Physical location : 76.942.272 - 76.944.650
Genatlas name see IMC2@
Synonym name
  • small inducible cytokine subfamily B (Cys-X-Cys), member 10
  • gamma IP10
  • interferon-inducible cytokine IP-10
  • 10 kDa interferon gamma-induced protein
  • small-inducible cytokine B10
  • Synonym symbol(s) IFIP10, INP10, IP-10, SCYB10, C7, SZ10, IFI10, IP-10, crg-2, mob-1, C7, gIP-10
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 2.38 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - D4S35 - D4S1 - MT2P1 - GC - ALB ALB /AFP AFP - IL8 - CXCL1 /PPBP /PF4 - CXCL5 /CXCL6 - CXCL11 - CXCL10 - CXCL10 - CXCL9 - qter
    Physical map
    BTC 4q13-q21 betacellulin DKFZP564O0823 4q13.3-q21.3 DKFZP564O0823 protein FLJ23604 4q21.21 hypothetical protein FLJ23604 ZNF363 4q21.1 zinc finger protein 363 THAP6 4q21.21 THAP domain containing 6 FLJ23657 4q21.21 hypothetical protein FLJ23657 CDKL2 4q21.21 cyclin-dependent kinase-like 2 (CDC2-related kinase) G3BP2 4q12-q21.1 cyclin-dependent kinase-like 2 (CDC2-related kinase) VDP 4q21.1 vesicle docking protein p115 PPEF2 4q13-q21 protein phosphatase, EF hand calcium-binding domain 2 ASAHL 4q21.1 N-acylsphingosine amidohydrolase (acid ceramidase)-like FLJ10498 4q21.21 hypothetical protein FLJ10498 CXCL9 4q21.2 chemokine (C-X-C motif) ligand 9 CXCL10 4q21.2 chemokine (C-X-C motif) ligand 10 CXCL11 4q21.2 chemokine (C-X-C motif) ligand 11 ART3 4p15.1-p14 ADP-ribosyltransferase 3 NUP54 4q21.1 nucleoporin 54kDa SCARB2 4q21.1 scavenger receptor class B, member 2 GENX-3414 4q24-q25 genethonin 1 FLJ25770 4q21.22 hypothetical protein FLJ25770 ShrmL 4q21.22 Shroom-related protein LOC152825 4q21.22 similar to ribosomal protein L26 LOC345079 4q21.22 similar to RIKEN cDNA 5730467H21 FLJ10849 4q21.22 hypothetical protein FLJ10849 AF357530 4q21.1 thioredoxin 1 pseudogene 3 CCNI 4pter-qter cyclin I LOC339966 4q21.22 similar to Gene product with similarity to Ubiquitin binding enzyme CCNG2 4q21.22 cyclin G2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1184 - 98 - 1996 8976378
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     pharynx   highly
    Endocrineparathyroid   highly
    Reproductivefemale systemuterus  highly
     male systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Cxcl10
    Homologene
    FAMILY
  • intercrine alpha (chemokine CxC) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • interferon gamma, T cells and NK cells chemoattractant
  • chemotactic for monocytes and T-lymphocytes
  • inducing cell death in neurons through calcium dysregulation
  • plays an important role in triggering beta cell destruction and diabetes
  • regulates liver inflammation response against ischemia/reperfusion injury
  • recruit donor-reactive T cells to the allograft, but is antagonistic costimulation molecule with CXCL9 during the priming of alloreactive T cell effectors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding CXCR3 (Ligand of CXCR3)
  • binding partner for TLR4 and a signal toward beta cell failure in diabetes
  • plays a central role in LCN2-induced cell migration( key role for LCN2-CXCL10 axis in cell migration and reactive astrocytosis following brain inflammation or injury)
  • CUX1 downregulates several NFKB-regulated chemokines such as CXCL10
  • cell & other
    REGULATION
    Other cleavage of the N-terminal two residues by DPP8
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in several neurodegenerative diseases, including multiple sclerosis, Alzheimer disease and HIV-associated dementia
    Susceptibility susceptibility to tuberculosis (TB)
    Variant & Polymorphism SNP new potential protective SNP (-135G>A) for TB is identified in the promoter of chemokine gene, CXCL-10
    Candidate gene
    Marker
    Therapy target
  • targeting CXCL10 may provide a novel therapeutic means to ameliorate liver ischemia/reperfusion injury in clinics
  • ANIMAL & CELL MODELS