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FLASH GENE
Symbol CXCL1 contributors: mct - updated : 16-10-2011
HGNC name chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
HGNC id 4602
Location 4q13.3      Physical location : 74.735.108 - 74.736.953
Synonym name
  • growth related oncogene (GRO alpha) see IMC2@
  • melanoma growth stimulating activity alpha
  • GRO1 oncogene (melanoma growth stimulating activity, alpha)
  • chemokine growth-regulated oncogene 1
  • fibroblast secretory protein
  • C-X-C motif chemokine 1
  • MGSA alpha
  • neutrophil-activating protein 3
  • keratinocyte-derived chemokine
  • Synonym symbol(s) GRO, GROA, MGSA, SCYB1, GRO1, GRO-1, MGSA-a, NAP-3, KC
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 1.85 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - IL8 - CXCL1 / PPBP / PF4 - CXCL5 / CXCL6 - CXCL2 / CXCL3 - CXCL11 - CXCL10 - CXCL9 - qter
    Authors O'Donovan et al. (1999)
    Physical map
    FLJ38991 4q21.1 hypothetical protein FLJ38991 ANKRD17 4q13.3 ankyrin repeat domain 17 HMGA1L2 4q21.1 high mobility group AT-hook 1-like 2 ALB 4q11-q13 albumin AFP 4q11-q13 alpha-fetoprotein AFM 4q11-q13 afamin RASSF6 4q21.21 Ras association (RalGDS/AF-6) domain family 6 IL8 4q13-q21 interleukin 8 CXCL6 4q21 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) PF4V1 4q13-q21 platelet factor 4 variant 1 CXCL1 4q21 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) CXCL1P 4q21.21 chemokine (C-X-C motif) ligand 1 pseudogene PF4 4q13-q21 platelet factor 4 (chemokine (C-X-C motif) ligand 4) PPBP 4q12-q13 pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) CXCL5 4q13-q21 chemokine (C-X-C motif) ligand 5 CXCL3 4q21 chemokine (C-X-C motif) ligand 3 SPBPBP 4q21.21 DNA-binding protein amplifying expression of surfactant protein B CXCL2 4q21 chemokine (C-X-C motif) ligand 2 LOC255324 4q21.21 similar to ALGV3072 EREG 4q25-q26 epiregulin AREG 4q13-q21 amphiregulin (schwannoma-derived growth factor) BTC 4q13-q21 betacellulin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1103 - 107 - 2000 11023497
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     stomach   highly
    Respiratorylung   highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Gro1
    Homologene
    FAMILY
  • intercrine alpha (chemokine CxC) family
  • ELR-CXC chemokine family
  • CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • growth regulator
  • melanoma growth stimulating activity
  • may play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion
  • potent inducer of senescence in stromal fibroblasts (depending on functional TP53), having a role for cell survival and the malignant transformation of ovarian epithelial cells
  • CXCL1 and CXCL2 play important roles in the infiltration of neutrophils into the site of injection of necrotic cells
  • both CXCL1 and CXCR2 play an important role in chemokine expression and neutrophil infiltration following adenoviral corneal infection, but have a redundant role in the development of keratitis
  • mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • plays an important role in leukocyte recruitment induced by both CXCL1 and CXCL2
  • is at least partially effective through LSP1 and the phosphorylation of MAPK14
  • serine-phosphorylated STAT1 bound to the promoters of the CXCL1 and CXCL2 genes and NFKB1 and STAT1 control CXCL1 and CXCL2 gene transcription
  • IL1B-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic beta-cells requires stimulus-induced changes in histone chemical modifications
  • cell & other
    REGULATION
    activated by RAS
    induced by Prokineticin 1 (induces CCL4, CXCL1 and IL8 in monocytes but not in macrophages and dendritic cells)
    IL17 (IL17 is a weak stimulus for transcription of the CXCL1 gene, it strongly potentiates message accumulation via stabilization when the mRNA is transcribed in cells stimulated with TNF)
    Other activation of monocytes in patients with rheumatoid arthritis
    IL1A regulates CXCL1, CXCL10, and ICAM1 in network form in oral keratinocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in ulcerative colitis, osteoarhtritis
    tumoral     --over  
    in ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • therapeutic target as well as a diagnostic marker in ovarian cancer
  • targeting CXCL1 for cancer therapy would be applicable to a large portion of human tumors with mutant TP53, but the exploration of CXCL1 as a potential target should take the mutation status of TP53 into consideration
  • ANIMAL & CELL MODELS