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FLASH GENE
Symbol CWC22 contributors: mct - updated : 25-08-2016
HGNC name CWC22 spliceosome-associated protein homolog (S. cerevisiae)
HGNC id 29322
Location 2q31.3      Physical location : 180.809.603 - 180.871.780
Genatlas name (complexed with Cef1)22 spliceosome-associated protein homolog (S. cerevisiae)
Synonym symbol(s) EIF4GL, KIAA1604, NCM, fSAPb
DNA
TYPE functioning gene
STRUCTURE 62.18 kb     20 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 3279 - 908 - 2011 20956557
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an MIF4G-like domain in the N-terminal region
  • a MA-3 domain in the middle region
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • associated with the spliceosome prior to catalytic steps and remains associated throughout the reaction
  • basic FUNCTION
  • required for pre-mRNA splicing but is neither tightly associated with the nineteen complex [NTC] nor required for spliceosome activation
  • might be associated with the spliceosome in a step after the binding of the NTC but prior to the first catalytic reaction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CWC22 and DHX16 bind to the spliceosome independently of each other (CWC22 is required for the productive function of DHX16 in the first catalytic step, but in the absence of CWC22, DHX16 binds to the spliceosome and dissociates upon ATP hydrolysis in a nonproductive manner)
  • CWC22 is a new EIF4A3 partner (duality of CWC22 function that hinders EIF4A3 from nonspecifically binding RNA and escorts it to the splicing machinery to promote exon-junction complex (EJC) assembly on mature mRNAs)
  • SLU7 adopts an extended conformation, binds PRPF8 and CWC22, and is poised for selection of the 3'-splice site
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS