basic FUNCTION
| negative regulator of cell cycle |
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inhibits cellular growth by a mechanism that involves cAMP, MAPK phosphorylation, and TP53 expression (Van Dort 2003) |
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involved in the regulation of cellular growth (Burnatowska-Hledin 2004) |
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component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal |
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degradation of target proteins |
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may be involved in proteosomal degradation of TP53 |
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stimulated by adenovirus E1B-55 kDa protein |
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CUL5-containing E3 ubiquitin ligase complex may play an important role in granulocytic differentiation (Baxter 2008) |
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plays an essential role in regulating neuron migrations during cortical development, possibly by opposing a promigratory effect of DAB1 (Feng 2007) |
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importance of CUL5 in multiple aspects of the cellular response to HSP90AA1 inhibition |
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involved in the formation of E3-specific ligase complexes that are responsible for delivering the ubiquitin protein to their target substrate proteins selected for ubiquitin-dependent degradation |
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CUL5 expression is affected by water deprivation in some tissues and there is a potential relationship between neddylated CUL5 and aquaporins |
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CUL5-containing ubiquitin ligases regulate a variety of signaling pathways by targeting particular substrates for proteasomal degradation or competing for protein–protein interactions |
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CUL5 functions as a novel tumor suppressor with prognostic relevance in Clear cell renal cell carcinoma (ccRCC) and is critically involved in the maintenance of genome stability |