protein
| covalently modified by NEDD8 |
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PRAME is a substrate recognition subunit of a CUL2-based E3 ubiquitin ligase |
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UBXN7 directly interacts with neddylated cullins and causes the accumulation of the CUL2 substrate HIF1A |
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molecular suppression of DCUN1D1 attenuates CUL2 neddylation |
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DCUN1D1 via its DAD patch binds to CUL2 but is also able to bind VHL independent of CUL2 and the DAD patch |
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CUL2 interacts with both the VHL BC box and cullin box and a novel ELOC site |
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expression of SQSTM1 inhibits the interaction of DCUN1D1 with CUL2 and attenuates the neddylation of CUL2, and thus downregulates the VHL E3 ligase complex activity (PMUID: 26743088) |
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PTCH1 intracellular domain (ICD7) interacted with most components of the CUL2 (CUL2)-based E3 ligase complex, including ELOC, ELOB, ZYG11B, and CUL2 itself |
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viral ANK/BC proteins target the host E3 ubiquitin ligase CUL2 via a C-terminal BC box domain and are potent suppressors of the production of inflammatory cytokines, including interferon |