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FLASH GENE
Symbol CUL2 contributors: mct - updated : 28-05-2020
HGNC name cullin 2
HGNC id 2552
Location 10p11.21      Physical location : 35.298.807 - 35.379.294
Synonym name
  • testis secretory sperm-binding protein Li 238E
  • Synonym symbol(s) MGC131970
    DNA
    TYPE functioning gene
    STRUCTURE 118.35 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 4205 - 745 - 2020 31898228
    21 - 4183 - 745 - 2020 31898228
    19 - 3994 - 682 - 2020 31898228
    21 - 4285 - 758 - 2020 31898228
    22 - 4346 - 614 - 2020 31898228
    21 - 4112 - 764 - 2020 31898228
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, checkpoint, G1S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    F-box containing protein
    HOMOLOGY
    interspecies homolog to C.elegans cul1
    Homologene
    FAMILY
  • C.elegans cullin family
  • Cdc53 (CUL) family member
  • CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text translocated to the nucleus by VHL
    basic FUNCTION
  • negative regulator of cell cycle
  • putatively targeting certain proteins for degradation
  • required for normal vasculogenesis, at least in part mediated by its regulation of HIF-mediated transcription
  • CELLULAR PROCESS cell cycle, checkpoint
    cell life, proliferation/growth
    cell life, cell death/apoptosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    text
  • negative regulator of cell proliferation
  • G1/S transition
  • PATHWAY
    metabolism
    signaling
    a component
  • complexing with VHL/elongin B and C to form an ubiquitin-ligase complex referred to VBC-CUL2(see VHL)
  • associating with the trimeric complex VHL, TCEB1 (elongin C), TCEB2 (elongin B)
  • component of the ElonginB/C-CUL2-RBX-1-Von Hippel-Lindau (VHL) tumor suppressor complex that ubiquitinates and degrades hypoxia-inducible factor (HIF1A)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • covalently modified by NEDD8
  • PRAME is a substrate recognition subunit of a CUL2-based E3 ubiquitin ligase
  • UBXN7 directly interacts with neddylated cullins and causes the accumulation of the CUL2 substrate HIF1A
  • molecular suppression of DCUN1D1 attenuates CUL2 neddylation
  • DCUN1D1 via its DAD patch binds to CUL2 but is also able to bind VHL independent of CUL2 and the DAD patch
  • CUL2 interacts with both the VHL BC box and cullin box and a novel ELOC site
  • expression of SQSTM1 inhibits the interaction of DCUN1D1 with CUL2 and attenuates the neddylation of CUL2, and thus downregulates the VHL E3 ligase complex activity (PMUID: 26743088)
  • PTCH1 intracellular domain (ICD7) interacted with most components of the CUL2 (CUL2)-based E3 ligase complex, including ELOC, ELOB, ZYG11B, and CUL2 itself
  • viral ANK/BC proteins target the host E3 ubiquitin ligase CUL2 via a C-terminal BC box domain and are potent suppressors of the production of inflammatory cytokines, including interferon
  • cell & other
    REGULATION
    Other conjugated by NEDD8 linked to tht regulatiion of hypoxia-inducible mRNAs,by VHL
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    high mRNA expression of CUL2, CUL4B, and CUL5 were correlated with better survival for breast cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS