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FLASH GENE
Symbol CTSW contributors: - updated : 05-04-2006
HGNC name cathepsin W (lymphopain)
HGNC id 2546
Location 11q13.1      Physical location : 65.647.283 - 65.651.212
Genatlas name lymphopain
Synonym symbol(s) LYPN, CATW
EC.number 3.4.22.-
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure ten coding exons
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Lymphoid/Immunespleen    
Respiratoryrespiratory tractlarynx   
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/HematopoieticNK cell
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • catalytic triad cysteine, histidine and asparagine with an insertion between histidine and asparagine
  • a short C terminal extension
  • HOMOLOGY
    interspecies homolog to murine Ctsw
    Homologene
    FAMILY papain superfamily, subgroup F-like protease
    CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION cysteine protease with a specific function in the mechanism or regulation of T-cell cytolytic activity
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by IL2 stimulation of NK cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS