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FLASH GENE
Symbol CTSO contributors: npt/mct - updated : 28/11/2008
HGNC name cathepsin O
HGNC id 2542
Location 4q32.1      Physical location : 156.845.275 - 156.875.048
Synonym symbol(s) CTSO1
EC.number 3.4.22.42
DNA
TYPE functioning gene
STRUCTURE 29.78 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC389234 4 LOC389234 TRIM2 4q31.3 tripartite motif-containing 2 ANXA2P1 4q21-q31 annexin A2 pseudogene 1 GAJ 4q31.3 GAJ protein KIAA0922 4q31.23 GAJ protein LOC285532 4q31.3 similar to JM5 protein TLR2 4q32 toll-like receptor 2 LOC285533 4q31.3 hypothetical protein LOC285533 SFRP2 4q31.3 secreted frizzled-related protein 2 FLJ20047 4q31.3 hypothetical protein FLJ20047 LOC389235 4 similar to protocadherin 16 precursor; fibroblast cadherin FIB1; fibroblast cadherin 1; dachsous homologue PLRG1 4q31.2-q32.1 pleiotropic regulator 1 (PRL1homolog, Arabidopsis) FGB 4q28 fibrinogen, B beta polypeptide FGA 4q28 fibrinogen, A alpha polypeptide FGG 4q28 fibrinogen, G gamma polypeptide LRAT 4q31.1-q31.23 lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) MGC27016 4q31.3 hypothetical protein MGC27016 LOC389236 4 LOC389236 NPY2R 4q31 neuropeptide Y receptor Y2 LOC389237 4 LOC389237 FLJ21159 4q31.3 hypothetical protein FLJ21159 GUCY1A3 4q31.1-q31.2 guanylate cyclase 1, soluble, alpha 3 GUCY1B3 4q31.3-q33 guanylate cyclase 1, soluble, beta 3 ACCN5 4q31.3-q32 amiloride-sensitive cation channel 5, intestinal TDO2 4q31-q32 tryptophan 2,3-dioxygenase CTSO 4q31-q32 cathepsin O FTHP2 4q31-q32 ferritin, heavy polypeptide pseudogene 2 PDGFC 4q32 platelet derived growth factor C GLRB 4q31.3 glycine receptor, beta LOC391707 4 similar to Chromatin accessibility complex protein 1 (CHRAC-1) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) GRIA2 4q32-q33 glutamate receptor, ionotropic, AMPA 2 DKFZp434L142 4q32.1 hypothetical protein DKFZp434L142 FLJ11155 4q32.1 hypothetical protein FLJ11155 LGR7 4q32.1 leucine-rich repeat-containing G protein-coupled receptor 7 ETFDH 4q33 electron-transferring-flavoprotein dehydrogenase LOC389238 4 LOC389238 PPID 4q31.3 peptidylprolyl isomerase D (cyclophilin D)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2943 35 321 - Santamaria (1998)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   lowly
Reproductivefemale systemovary  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta highly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to C.elegans y113g7b.15
Homologene
FAMILY
  • papain family of thiol proteases (peptidase family C1)
  • cysteine proteinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • cysteine proteinase (endopeptidase), involved in cellular protein degradation and turnover
  • may play an important role in extracellular matrix degradation
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by trans-epoxysuccimyl-L-leucylamino-(4-guanidino) butane (E-64) [enzymatic activity abolished]
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS