| SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,nucleus
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| text
| secretory vesicles form or lysosomal form |
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CTSL and CTSB colocalize to the secretory granule compartment of skin mast cells  |
| basic FUNCTION
| cysteine proteinase cleaving collagen and elastin |
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involved in matrix degradation during endochondral ossification |
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having a critical role in the integration of circulating endothelial progenitor cells into ischemic tissue and is required for endothelial progenitor cells -mediated neovascularization |
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playing a potent role in degrading collagen, laminin, and implicated in tumor invasion and metastasis |
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playing a major role in intracellular protein catabolism |
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functioning as a prohormone -processing enzyme for production of the enkephalin peptide neurotransmitter(through secretory vesicules) |
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playing a role in peptide generation for MHC class 2 presentation |
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functions as a proneuropeptide processing enzyme for the conversion of proenkephalin to mature (Met)enkephalin, an opioid peptide neurotransmitter and hormone, as a distinct cysteine protease pathway for producing the enkephalin member of neuropeptides |
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playing an intracellular role in normal intestinal epithelial polarization and initiation of neoplasia |
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role in the degradation of the matrix protein fibronectin, insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R), essential molecules for adipogenesis and glucose metabolism |
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may play important roles during normal placentation and in the etiology of pre-eclampsia |
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stabilizes epigenetic heterochromatin markers on pericentromeric heterochromatin and the Y chromosome through a novel mechanism that does not involve DNA methylation or affect heterochromatin structure and operates on both somatic and sex chromosomes |
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participates as a key proteolytic enzyme for NPY production in secretory vesicles |
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biological role in the production of NPY, a peptide neurotransmitter, and neuroendocrine hormone |
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responsible for processing and activation of proheparanase through multiple cleavages of a linker segment |
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important lysosomal proteinase involved in a variety of cellular functions including intracellular protein turnover, epidermal homeostasis, and hair development |
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improves cardiac function and inhibits cardiac hypertrophy, inflammation, and fibrosis through blocking AKT/GSK3B signaling |
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lysosomal proteinase whose expression is also up-regulated in the skeletal muscle during starvation |
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with CTSL, and CTSK, implicated in atherogenesis |
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CTSL1 and CTSB are central to the processing of protryptase(s) in human mast cells |
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CTSL, CTSZ, account for the lysosome's capacity to digest polyQ sequences, and are important in defending against the accumulation and toxicity of polyQ proteins |
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within lysosomes, CTSL is a major, probably the only, rate-limiting protease in the digestion of polyQ repeats in proteins, although many other lysosomal proteases can degrade the typical polypeptide sequences in myoglobin |
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CTSB, CTSK, CTSL1, CTSS may be putative leptin activity regulators in white adipose tissue (WAT) |
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negatively regulates bone marrow (BM) B-cell production and output therefore influencing the homeostasis of peripheral B cells |
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lysosomal CTSL attenuates cardiac hypertrophy and preserves cardiac function through facilitation of autophagy and proteasomal protein processing |
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cysteine protease that degrades the peri-tumoral tissue |
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CTSB and CTSL are essential in SNCA lysosomal degradation, establishing groundwork to explore mechanisms to enhance their cellular activity and levels as a potential strategy for clearance of SNCA |
