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FLASH GENE

Symbol

CTSF

contributors: npt/mct - updated : 28/11/2008

HGNC name	cathepsin F
HGNC id	2531

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q13.1      Physical location : 66.330.935 - 66.336.047
Synonym symbol(s)	CATSF
EC.number	3.4.22.41

DNA

TYPE	functioning gene
STRUCTURE	5.11 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CTSF 13 - 2032 53 484 - Kaakinen (2007)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly Nervous nerve       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	resulting from a gene fusion between an ancestral cystatin and cathepsin
	a hydrophobic signal sequence
	a long propeptide domain
	a ERFNAQ motif
	a catalytic region including an essential cysteine residue
	a signal peptide targeting CTSF to the lysosomal compartment

isoforms

Precursor

HOMOLOGY

Homologene

FAMILY	peptidase C1 family
	papain cysteine protease (C1) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	cysteine proteinase, involved in degradative processes during tumor progression
	play a central role on the enhancement of tumor-induced angiogenesis, cell migration, proliferation, apoptosis and connective tissue degradation
	with angiotensin II participate in atherosclerosis, particularly in remodeling of the extracellular matrix of the inflamed arterial intima

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

text	proteolysis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in cervical carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS