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FLASH GENE
Symbol CTNNAL1 contributors: mct/npt/pgu - updated : 02-09-2009
HGNC name catenin (cadherin-associated protein), alpha-like 1
HGNC id 2512
Location 9q31.3      Physical location : 111.704.850 - 111.775.764
Synonym name
  • adhesion molecule catenin alpha-like 1
  • alpha-catulin
  • alpha2-catulin
  • Synonym symbol(s) CLLP, ACATU, alpha-CATU, ACRP, FLJ08121, CTNNAL
    DNA
    TYPE functioning gene
    STRUCTURE 70.91 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 2445 81.7 734 - 2008 18374411
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • potential casein kinase and protein kinase C phosphorylation site
  • tyrosine kinase phosphorylation site
  • HOMOLOGY
    interspecies homolog to Catnal1
    intraspecies homolog to alpha-catenin and vinculin
    Homologene
    FAMILY
  • vinculin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • modulating Rho pathway signaling by providing a scaffold for the Lbc Rho guanine -nucleotide exchange factor
  • may contribute to the wound repair and proliferation of bronchial epithelial cells and may serve to fibronectin mediated cell-extracellular adhesion and its signal transduction
  • is a unique regulator of GPCR signaling and represents a unique expansion of the intricate and continually evolving array of GPCR signaling networks
  • have tumorigenic potential because it regulates the nuclear factor-KB (NFKB) pathway
  • promotes tumor growth by preventing cellular senescence
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the E cadherin multiprotein complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with AKAP13 (may modulate Rho pathway signaling by providing a scaffold for the AKAP13 Rho guanine nucleotide exchange factor)
  • DTNA recruits alpha-catulin (CTNNAL1) to the ADRA1D/dystrophin-associated protein complex signalosome
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in placentas of preeclampsia and HELLP syndrome
    tumoral     --over  
    in oral squamous cell carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    downregulating alpha-catulin may be a promising therapeutic approach for cancer treatment
    ANIMAL & CELL MODELS