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FLASH GENE
Symbol CTNNA1 contributors: mct - updated : 21-02-2015
HGNC name catenin (cadherin-associated protein), alpha 1, 102kDa
HGNC id 2509
Location 5q31.2      Physical location : 138.089.106 - 138.270.722
Synonym name
  • alpha E-catenin
  • renal carcinoma antigen NY-REN-13
  • alpha-catenin
  • Synonym symbol(s) CAP102, CTN1, FLJ36832, FLJ52416, alpha-cat, CTNNA
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text
  • CTNNA genes contain antisense oriented leucine rich repeat transmembrane (LRRTM) genes within their seventh introns (CTNNA1 containing LRRTM2)
  • STRUCTURE 181.62 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • share bidirectional promoters with LRRTM2
  • novel 5prime exon VIIb containing CTNNA1 transcripts are expressed in the nervous system at higher levels than in other tissues
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3778 100.1 906 widely, and expressed at similar levels in most brain regions but higher levels in the corpus callosum and dorsal pons 2011 21708131
  • CTNNA1A
  • 321 bp extension in the 3'utr
  • - polyA site 3457 59.6 536 strongly expressed in the brain and cerebellum (higher expression levels in the frontal and occipital lobe, corpus mammilare and cerebellum), moderately in the placenta, liver and lung 2011 21708131
  • CTNNA1B
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
    Nervousbrain   highly
    Reproductivefemale systembreastmammary gland highly
     female systemovary  highly
     female systemuterus  highly
    Skin/Tegumentskin   predominantly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumcardiac highly
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    mono polymer homomer , monomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Catna1
    ortholog to murine Ctnna1
    homolog to zebrafish ctnna
    intraspecies homolog to vinculin
    Homologene
    FAMILY
  • vinculin/alpha-catenin family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,desmosome
        intracellular
    intracellular,cytoplasm,cytosolic
    text colocalizes with CTNNA1 at the intercalated discs of cardiomyocytes and in peritubular myoid cells of testis
    basic FUNCTION
  • regulating cell adhesion
  • playing a crucial role in cell differentiation
  • directly regulating actin-filament organization by suppressing Arp2/3-mediated actin polymerization
  • connecting cell-density-dependent adherens junctions with the developmental hedgehog pathway and providing a negative feedback loop controlling the size of developing cerebral cortex
  • associated with E-cadherin play a critical role in the regulation of cell-cell adhesion
  • key regulator of beta-catenin transcriptional activity and the status of CTNNA1 expression in prostatic tumor tissues might have prognostic value for SRC targeted therapy
  • forced expression of CTNNA1 in cancer cells can restore both higher intercellular avidity and intercellular E-cadherin bond strength
  • essential for the regulation of cell–cell and cell–matrix interactions in tissues
  • epithelial cells remodel their junctional architecture by responding to mechanical forces, and CTNNA1-bound LIMA1 acts as a mechanosensitive regulator for this process
  • plasticity of the CDH5-CTNNA1 complex is central for the leukocyte diapedesis mechanism
  • central role of CTNNA1 in global cytoskeleton remodelling, in which it acts not only on actin but also on MT reorganisation during epithelial morphogenesis
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    molecular pathway PTEN-CEBPA-CTNNA1 which is evolutionarily conserved, and controls myeloid development and transformation
    a component
  • constituent of the E cadherin multiprotein complex
  • constituent of desmosomal plaque
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLLT4
  • F-actin
  • cadherin
  • vinculin
  • association of CTNNA1 with the cadherin-catenin complex is required for efficient leukocyte transendothelial migration
  • interacting with JNK (JNK affects the association of CTNNA1 with the adherens junction complex and regulates adherens junctions)
  • is the most common interaction partner of YAP1 in keratinocytes (is crucial for the inactivation of YAP1 in keratinocytes)
  • CTNNA1/CTNND1 contact within the cadherin-catenin complex can regulate cadherin trafficking
  • AJUBA associates with CTNNA1 and its localization to adherens junctions and association with CTNNA1 are promoted by cytoskeletal tension
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation     loss of function
    loss of function by somatic mutation in lung, prostate, ovarian colon cancer cell lines
    tumoral     --low  
    by hypermethylation, more common in AML patients with 5q deletion than those without 5q deletion
    Susceptibility
    Variant & Polymorphism
    Candidate gene loss of expression of the alpha-catenin tumor suppressor in hematopoietic stem cells may provide a growth advantage that contributes to human MDS or AML with del(5q)
    Marker
    Therapy target
    ANIMAL & CELL MODELS