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FLASH GENE
Symbol CTF1 contributors: mct - updated : 11-09-2018
HGNC name cardiotrophin 1
HGNC id 2499
Location 16p11.2      Physical location : 30.907.927 - 30.914.880
Synonym name cardiophin 1
Synonym symbol(s) CT1, CT-1
DNA
TYPE functioning gene
STRUCTURE 7.74 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC51333 16p12.1 mesenchymal stem cell protein DSC43 XTP3TPA 16p12.1 XTP3-transactivated protein A SEPHS2 16p12.1 selenophosphate synthetase 2 ITGAL 16p11.2 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) FLJ23436 16p11.2 hypothetical protein FLJ23436 MGC2474 16p11.2 hypothetical protein MGC2474 LOC388244 16 LOC388244 MGC13138 16p11.2 hypothetical protein MGC13138 LOC146542 16p11.2 similar to hypothetical protein MGC13138 FLJ32130 16p11.2 hypothetical protein FLJ32130 LOC115509 16p11.2 hypothetical protein BC014000 MGC3121 16p11.2 hypothetical protein MGC3121 FBS1 16p11.2 fibrosin 1 LOC388245 16 LOC388245 SRCAP 16p11.2 LOC388245 PHKG2 16p11.2-p12.1 phosphorylase kinase, gamma 2 (testis) LOC388246 16 LOC388246 RNF40 16p11.2-p11.1 ring finger protein 40 KIAA0326 16p11 ring finger protein 40 LOC390690 16 similar to Protein C20orf27 BCL7C 16p11 B-cell CLL/lymphoma 7C CTF1 16p11.2-p11.1 cardiotrophin 1 LOC283932 16p11.2 hypothetical protein LOC283932 MGC13024 16p11.2 hypothetical protein MGC13024 KIAA0339 16p11 hypothetical protein MGC13024 HSD3B7 16p11.2-12 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 STX1B2 16p12-p11 syntaxin 1B2 STX4A 16p13.13-p12.3 syntaxin 4A (placental) FLJ13479 16p11.2 hypothetical protein FLJ13479 KIAA0296 16p13.13-p13.2 hypothetical protein FLJ13479 IMAGE3455200 BCKDK 16p11.2 branched chain alpha-ketoacid dehydrogenase kinase MYST1 16p11.2 MYST histone acetyltransferase 1 PRSS8 16p11.2 protease, serine, 8 (prostasin) FLJ90661 16p11.2 hypothetical protein FLJ90661 LOC390691 16 similar to Filamin B (FLN-B) (Beta-filamin) (Actin-binding like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP-280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1) FUS 16p11.2 fusion, derived from t(12;16) malignant liposarcoma ASC 16p12-p11.2 fusion, derived from t(12;16) malignant liposarcoma PYC1 16p11.2 pyrin-domain containing protein 1 ITGAM 16p11.2 integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1681 - 201 - 2017 28785017
3 - 1678 - 200 - 2017 28785017
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver     Homo sapiens
Nervousgangliasensory gangliadorsal root  
Reproductivefemale systemovary   
Respiratorylung    
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
Muscularstriatumskeletal  
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoclast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text fetal kidney and lung,;eye,lens choroid RPE,retina,,eye anterior segment
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY interleukin-6 cytokine family member
CATEGORY signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • activating the leukemia inhibitory factor receptor (LIF receptor)/GP 130 receptor complex
  • embryonic neurons regulate the onset of cortical gliogenesis via CTF1
  • is a natural defense of the liver against apoptosis
  • may now be classed as an essential osteoclast-derived stimulus of both bone formation and resorption
  • acts as a chromatin domain boundary that shields human telomeric genes from silencing
  • induces VSMCs proliferation, hypertrophy and extracellular matrix production, and is upregulated in hypertension and by aldosterone
  • is a master regulator of fat and glucose metabolism
  • heart-targeting cytokine that is increased in the metabolic syndrome due to overexpression in the adipocytes
  • role for CTF1 in the regulation of myocardial glucose metabolism
  • role in lipid metabolism regulation and adipose tissue function
  • ability of CTF1 to regulate the activity of the main lipases underlies the lipolytic action of this cytokine and could contribute to CTF1 antiobesity effects
  • key regulator of energy homeostasis, as well as glucose and lipid metabolism
  • stimulates beneficial myogenic and vascular remodeling of the heart
  • is a factor capable of recapitulating the key features of physiologic growth of the heart including transient and reversible hypertrophy of the myocardium, and stimulation of cardiomyocyte-derived angiogenic signals leading to increased vascularity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IL6ST in heart failure (downregulation of IL6ST)
  • activates NOTCH1 signaling through the up-regulation of ADAM10, a rate-limiting factor of NOTCH1 signaling activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in congestive heart failure and dilated cardiomyopathy
    constitutional     --low  
    in non-diabetic subjects who were overweight or obesity having significantly lower cardiotrophin-1 concentrations than those with normal weight
    constitutional     --over  
    significantly elevated in untreated patients with grade I essential hypertension (EH) patients compared with normotensive (NT) subjects
    constitutional     --over  
    in hypertension and in heart failure
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    represents an interesting target to influence insulin sensitivity
    miscelleaneoushypertension 
    may represent a new target of vascular wall remodeling in hypertension
    ANIMAL & CELL MODELS
  • Cardiotrophin-1 null mice presented decreased arterial stiffness
  • ct-1(-/-) mice develop mature-onset obesity, insulin resistance, and hypercholesterolemia despite reduced calorie intake