basic FUNCTION
| activating the leukemia inhibitory factor receptor (LIF receptor)/GP 130 receptor complex |
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embryonic neurons regulate the onset of cortical gliogenesis via CTF1 |
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is a natural defense of the liver against apoptosis |
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may now be classed as an essential osteoclast-derived stimulus of both bone formation and resorption |
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acts as a chromatin domain boundary that shields human telomeric genes from silencing |
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induces VSMCs proliferation, hypertrophy and extracellular matrix production, and is upregulated in hypertension and by aldosterone |
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is a master regulator of fat and glucose metabolism |
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heart-targeting cytokine that is increased in the metabolic syndrome due to overexpression in the adipocytes |
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role for CTF1 in the regulation of myocardial glucose metabolism |
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role in lipid metabolism regulation and adipose tissue function |
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ability of CTF1 to regulate the activity of the main lipases underlies the lipolytic action of this cytokine and could contribute to CTF1 antiobesity effects |
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key regulator of energy homeostasis, as well as glucose and lipid metabolism |
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stimulates beneficial myogenic and vascular remodeling of the heart |
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is a factor capable of recapitulating the key features of physiologic growth of the heart including transient and reversible hypertrophy of the myocardium, and stimulation of cardiomyocyte-derived angiogenic signals leading to increased vascularity |