basic FUNCTION
| is a unique chromatin-associated, Ser5-preferential CTD phosphatase that preferentially distributes to transcriptionally silenced gene regions and may participate in gene regulation during erythroid differentiation |
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is a novel regulator of FOXO transcription factors and promotes cellular proteolysis |
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regulates hepatic gluconeogenesis |
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role in protecting cells from apoptosis induced by oxidative stress |
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CTDSPL and CTDSPL2 have oncogenic properties, including promoting cell migration |
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is a critical regulator of epithelial-to-mesenchymal transition (EMT) by both suppressing epithelial gene expression and promoting mesenchymal gene expression |
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is a mitotic regulator |
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novel role of CTDSPL2 in regulating cell mitosis, proliferation and motility in pancreatic cancer |