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FLASH GENE
Symbol CTDSPL2 contributors: mct - updated : 15-02-2023
HGNC name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
HGNC id 26936
Location 15q15.3      Physical location : 44.719.578 - 44.819.427
Synonym symbol(s) HSPC129, FLJ10523, HSPC058, SCP4
DNA
TYPE functioning gene
STRUCTURE 101.41 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 6433 - 466 - 2010 20932329
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY small CTD phosphatase (SCP) family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • is a unique chromatin-associated, Ser5-preferential CTD phosphatase that preferentially distributes to transcriptionally silenced gene regions and may participate in gene regulation during erythroid differentiation
  • is a novel regulator of FOXO transcription factors and promotes cellular proteolysis
  • regulates hepatic gluconeogenesis
  • role in protecting cells from apoptosis induced by oxidative stress
  • CTDSPL and CTDSPL2 have oncogenic properties, including promoting cell migration
  • is a critical regulator of epithelial-to-mesenchymal transition (EMT) by both suppressing epithelial gene expression and promoting mesenchymal gene expression
  • is a mitotic regulator
  • novel role of CTDSPL2 in regulating cell mitosis, proliferation and motility in pancreatic cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a SMAD phosphatase, playing a critical role in BMP-induced signaling and cellular functions
  • CTDSPL2 acts as a novel SNAI1 phosphatase
  • plays a critical role in EMT through SNAI1 dephosphorylation and stabilization
  • cell & other
    REGULATION
    Phosphorylated by at T86, S104, and S134 by cyclin-dependent kinase 1 (CDK1) in mitosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in skeletal muscle of patients with Chronic kidney disease (CKD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    alternative molecular target for pancreatic cancer treatment
    diabetetype 2 
    could serve as a potential target for the prevention and treatment of diet-induced glucose intolerance and type 2 diabetes
    ANIMAL & CELL MODELS