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FLASH GENE
Symbol CTDSP1 contributors: - updated : 23-09-2005
HGNC name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
HGNC id 21614
Location 2q35      Physical location : 219.264.477 - 219.270.663
Synonym name
  • small CTD phosphatase 1
  • nuclear LIM interactor-interacting factor
  • golli-interacting protein
  • Synonym symbol(s) NLI-IF, NLIIF, SCP1, GIP
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text
  • transcribed in the same orientation as NRAMP1
  • the genomic interval between the end of exon 15 of NRAMP1 and the transcriptional start site of NLIIF is exactly 3,961 bp
  • STRUCTURE 6.00 kb     7 Exon(s)
    regulatory sequence Binding site   transcription factor
    text structure a putative regulatory elements including consensus binding sequence for SP1,AP2,NFKB,PU1
    MAPPING cloned Y linked N status provisional
    Physical map
    TNS 2q35-q36 tensin FLJ46536 2q35 FLJ46536 protein IL8RB 2q35 interleukin 8 receptor, beta IL8RA 2q35 interleukin 8 receptor, alpha ARPC2 13q12-q13 actin related protein 2/3 complex, subunit 2, 34kDa GPBAR1 2q36.1 G protein-coupled bile acid receptor 1 AAMP 2q36.1 angio-associated, migratory cell protein MR-1 2q35 myofibrillogenesis regulator 1 PP1201 2p24.3-p24.1 PP1201 protein MGC50811 2q35 hypothetical gene supported by BC052750 SLC11A1 2q35 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 CTDSP1 2q35 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 VIL1 2q35 villin 1 USP37 2q35 ubiquitin specific protease 37 RQCD1 2q36.1 RCD1 required for cell differentiation1 homolog (S. pombe) PLCD4 2q35 phospholipase C, delta 4 ZNF142 2q34-q35 zinc finger protein 142 (clone pHZ-49) BCS1L 2q33 BCS1-like (yeast) RNF25 2q36.1 ring finger protein 25 STK36 2q35 serine/threonine kinase 36 (fused homolog, Drosophila) KIAA0173 2p24.3-p24.1 serine/threonine kinase 36 (fused homolog, Drosophila) CYP27A1 2q35-q36 cytochrome P450, family 27, subfamily A, polypeptide 1 PRKAG3 2q35 protein kinase, AMP-activated, gamma 3 non-catalytic subunit LOC391484 2 similar to 60S ribosomal protein L23a WNT6 2q35 wingless-type MMTV integration site family, member 6 WNT10A 2q35 wingless-type MMTV integration site family, member 10A LOC391485 2 similar to cytokeratin 8 CDK5R2 2q35 cyclin-dependent kinase 5, regulatory subunit 2 (p39) HSRNAFEV 2q33 cyclin-dependent kinase 5, regulatory subunit 2 (p39) CRYBA2 2q34-q36 crystallin, beta A2 DKFZp434O0527 2q36.1 hypothetical protein DKFZp434O0527
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2655 - 261 - Yeo
    - - 783 - 260 - Yeo
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    Nervousoligodendrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta predominantly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    NLI-interacting factor motif
    HOMOLOGY
    interspecies ortholog to gallus Nliif
    homolog to yeast S. cerevisiae Psr2p
    homolog to cow Bt.6646
    homolog to murine Nif3
    homolog to Drosophila CG5830
    homolog to C.elegans B0379.4b
    intraspecies homolog to human FCP1
    Homologene
    FAMILY NIF family
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text cytoplasmic protein translocated to the nucleus
    basic FUNCTION may play a role in the regulation of gene expression, possibly by controlling the transition from initiation/capping to processive transcript elongation
    CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with golli and LDB1 (NLI) in the nucleus in a complex that may regulate gene transcription in neural cells
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Mg2+ dependent
    protein
  • binding to LDB1
  • interacting with RNAP II
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS