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FLASH GENE

Symbol

CTDSP1

contributors: - updated : 23-09-2005

HGNC name	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
HGNC id	21614

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q35      Physical location : 219.264.477 - 219.270.663
Synonym name	small CTD phosphatase 1
	nuclear LIM interactor-interacting factor
	golli-interacting protein
Synonym symbol(s)	NLI-IF, NLIIF, SCP1, GIP
EC.number	3.1.3.16

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
text	transcribed in the same orientation as NRAMP1
	the genomic interval between the end of exon 15 of NRAMP1 and the transcriptional start site of NLIIF is exactly 3,961 bp
STRUCTURE	6.00 kb     7 Exon(s)

regulatory sequence	Binding site   transcription factor
text structure	a putative regulatory elements including consensus binding sequence for SP1,AP2,NFKB,PU1

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed Variant 1 - - 2655 - 261 - Yeo Variant 2 - - 783 - 260 - Yeo

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Nervous oligodendrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta predominantly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

NLI-interacting factor motif

HOMOLOGY

interspecies	ortholog to gallus Nliif
	homolog to yeast S. cerevisiae Psr2p
	homolog to cow Bt.6646
	homolog to murine Nif3
	homolog to Drosophila CG5830
	homolog to C.elegans B0379.4b

intraspecies

homolog to human FCP1

Homologene

FAMILY

NIF family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	cytoplasmic protein translocated to the nucleus

basic FUNCTION

may play a role in the regulation of gene expression, possibly by controlling the transition from initiation/capping to processive transcript elongation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

complexing with golli and LDB1 (NLI) in the nucleus in a complex that may regulate gene transcription in neural cells

INTERACTION

DNA

RNA

small molecule	metal binding,
	Mg2+ dependent

protein	binding to LDB1
	interacting with RNAP II

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS