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FLASH GENE
Symbol CTDNEP1 contributors: mct - updated : 29-06-2011
HGNC name dullard homolog (Xenopus laevis)
HGNC id 19085
Location 17p13.1      Physical location : -
Synonym name dullard homolog
Synonym symbol(s) HSA011916, NET56, DULLARD
EC.number 3.1.3.16
DNA
TYPE functioning gene
STRUCTURE 8.10 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1545 28.2 244 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Digestiveliver   moderately
Endocrinepancreas   highly
Nervousbrain   highly
Reproductivemale systemprostate  highly
Respiratorylung   highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-terminal conserved domain of NLI-IF (Nuclear LIM Interactor-Interacting Factor)
  • HOMOLOGY
    interspecies homolog to rattus Rn.4211
    homolog to murine Dullard
    homolog to Xenopus Xl.5594
    homolog to Zebrafish Dr.7581
    homolog to Drosophila CG1696
    homolog to C.elegans F45E12.1
    Homologene
    FAMILY
  • DXDX(T/V) phosphatase family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • playing a necessary role for neural development
  • involved in neural development, and functioning as a negative regulator of BMP signaling
  • promotes BMPR degradation via the lipid raft-caveolar pathway
  • dephosphorylates LPIN1, LPIN2, LPIN3, and potentially participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, cascades conserved from yeast to mammals (
  • having specificity for the peptide corresponding to the insulin-dependent phosphorylation site (Ser106) of lipin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neural development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with BMP type I receptors and represses the BMP-dependent phosphorylation of the BMP type I receptor
  • interacting with LPIN1, LPIN2, LPIN3 (Lipin cellular location, protein partners, and biological function are directed by phosphorylation-dephosphorylation events catalyzed by the phosphoserine phosphatase CTDNEP1) )
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS