| basic FUNCTION
| DNA-binding protein that plays essential roles in regulating genome activity through its capacity to act as an enhancer blocker |
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required for the enhancer blocking activity of vertebrate insulators (DNA sequence that can act as a barrier to the influences of neighboring cis-acting elements, preventing gene activation)  |
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binding to imprinting control region (ICR) to maintain but not establish the differential methylation of ICR |
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putative trans-acting factor for X-inactivation choice, maybe together with TSIX |
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having insulator function (regulating access of enhancers to promoters) and protecting regions from DNA methylation |
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involved in transcriptional activation, insulation and genomic imprinting, but also in transcriptional repression |
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mediating interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1 |
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playing a role in gene silencing or activation, chromatin insulation and genomic imprinting |
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participates in key cellular mechanisms underlying immortality by regulating TERT gene expression |
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largely determines the localization of cohesins (cohesin recruitment by CTCF provides a mechanism for the selective positioning of cohesins on chromosome arms) |
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involved in imprinting, long-range chromatin interactions and transcription |
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positively regulates cell growth in rapidly dividing thymocytes so that appropriate number of cells are generated before positive and negative selection in the thymus |
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important protein involved in chromatin organization and the epigenetic regulation of gene expression |
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multifunctional protein that involves regulation of growth factor- and cytokine-induced cell proliferation/differentiation |
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down stream target of stress-induced signaling cascades and it plays a significant anti-apoptotic role in regulation of stress-induced cellular responses in corneal epithelial and hematopoietic myeloid cells |
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master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region |
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organizes transcription and chromatin in the three-dimensional space of the nucleus |
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with other sequence-specific DNA binding factors, recruits cohesin to specific chromosomal locations |
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role for CTCF in mediating chromatin loops, presumably different chromatin loops than those that involve ESR1 and FOXA1 during estrogen-mediated transcription in breast cancer cells |
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stimulates muscle gene expression by favoring MYOD1 recruitment |
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regulates Wnt signaling, linking CTCF to broad aspects of development |
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plays an important role in insulation and in large-scale organization of chromatin within the eukaryotic nucleus, that depends for both activities on recruitment of the cohesin complex |
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most characterized insulator-binding protein, implicated as a key genome organizer |
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enhancer bridging' activity that could potentially engage CTCF in generating cell-specific chromatin interactions and guide gene expression programs |
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unappreciated role for CTCF and cohesins in the repression of imprinted genes in somatic cells |
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CTCF-dependent chromatin insulation plays a pivotal role in governing physiological vascular growth |
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negatively regulates tumor angiogenesis |
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governs normal vascular formation in the developing retina, and depletion of CTCF causes excess intraretinal neovascularization |
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CTCF is a master regulator of genome spatial organization, and mediates the ubiquitous chromatin loops within the genome |
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functions as a switch-like molecule between the insulin signaling and the regulations of PAX6 and glucagon expression in pancreatic islet alpha-cells |
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CTCF and cohesin are integral components of most human subtelomeres, and important for the regulation of TERRA transcription and telomere end protection |
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potentially required for enhancer-driven gene activation and genomic interaction of enhancers and their regulated gene promoters in development |
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has a complex role in regulating FMR1 expression, probably through the organization of chromatin loops between sense/antisense transcriptional regulatory regions, as suggested by bioinformatics analysis |
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constitutive CTCF sites may play a role in organizing/maintaining the recently identified topological domains that are common across most human cells |
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crucial regulator of long-range chromatin interactions and coordinates specific communication between transcription factors and gene expression processes |
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novel role of CTCF and cohesin as regulators of transcriptional direction |
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role of CTCF in stabilizing long-range interactions between chromatin sites essential for maintaining nuclear architecture |
