basic FUNCTION
| when coexpressed, OBFC1 and CTC1 formed an AAF complex that stimulated DNA primase activity or human polymerase-alpha-primase (Casteel 2009) |
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participates in telomere maintenance in diverse species and a CST-like complex is required for telomere integrity in multicellular organisms (Surovtseva 2009) |
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appears to function in a telomere-associated complex with OBFC1 and TEN1 (Miyake 2009) |
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may have a function in DNA metabolism that is necessary for but not specific to telomeric integrity |
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CTC1/OBFC1/TEN1 rescues stalled replication forks during conditions of replication stress, such as those found at natural replication barriers, likely by facilitating dormant origin firing |
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CTC1 and ZNF676 are genes regulating telomere homeostasis |
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CST (CTC1-OBFC1-TEN1) complex is directly involved at several stages of telomere end formation |
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TEN1 likely functions in conjunction with CTC1 and OBFC1 at the telomere and elsewhere in the genome |