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FLASH GENE
Symbol CTBP2 contributors: mct/npt - updated : 11-07-2012
HGNC name C-terminal binding protein 2
HGNC id 2495
Location 10q26.13      Physical location : 126.676.418 - 126.849.624
Synonym name
  • ribeye
  • Synonym symbol(s) RIBEYE
    DNA
    TYPE functioning gene
    STRUCTURE 173.21 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence alternative promoter
    MAPPING cloned Y linked N status provisional
    Physical map
    ACADSB 10q25-q26 acyl-Coenzyme A dehydrogenase, short/branched chain LOC340784 10q26.13 similar to NK-type homeobox LOC387716 10 similar to Hmx2 protein LOC387717 10 LOC387717 BUB3 10q26 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) LOC390009 10 similar to 40S ribosomal protein S26 GPR26 10q26.2-q26.3 G protein-coupled receptor 26 DKFZp761H2121 10q26.13 hypothetical protein DKFZp761H2121 LOC119587 10q26.13 hypothetical protein LOC119587 GALNAC4S-6ST 10q26 hypothetical protein LOC119587 FLJ12616  hypothetical protein FLJ12616 LOC340735 10q26.2 similar to germ cell specific Y-box binding protein; contrin OAT 10q26 ornithine aminotransferase (gyrate atrophy) OATL3 10q26 ornithine aminotransferase-like 3 (pseudogene) LOC390010 10 similar to Sax-1 LHPP 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase KIAA0140 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase KIAA0157 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase ZRANB1 10q26.13 zinc finger, RAN-binding domain containing 1 CTBP2 21q21.3 C-terminal binding protein 2 MRPS21P6 10q26 mitochondrial ribosomal protein S21 pseudogene 6 LOC387718 10 hypothetical gene supported by AK131010; BC062717 LOC387719 10 LOC387719 EDRF1 10q26.2 erythroid differentiation-related factor 1 MMP21 10q26.3 matrix metalloproteinase 21 UROS 10q25.2-q26.3 uroporphyrinogen III synthase (congenital erythropoietic porphyria) BCCIP 10q26.1 BRCA2 and CDKN1A interacting protein DDX32 10q26.3 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32 FANK1 10q26.2 fibronectin type 3 and ankyrin repeat domains 1 ADAM12 10q26.3 a disintegrin and metalloproteinase domain 12 (meltrin alpha) FLJ32938 10q26.2 hypothetical protein FLJ32938
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 initiation site 3428 48.9 445 - 2008 18264096
  • using an alternate inframe exon 1
  • involved in transcriptional repression
  • transcribed from distinct promoters
  • 9 initiation site 4752 120 985 - 2008 18264096
  • localized to synoptic ribbons in the retina
  • using for fast tonic neurotransmitter release in a subset of specialized neurons
  • transcribed from distinct promoters
  • 11 - 3441 - 445 - 2008 18264096
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestine   highly
    Endocrinepancreas   highly
    Nervousnerve   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain may contribute a unique transcriptional regulatory activity of CTBP2
  • a 6 AA motif highly conserved among the E1A proteins
  • a NAD+ binding domain
  • conjugated PhosphoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Ctbp2
    homolog to C.elegans F19e10.5
    intraspecies homolog to CTBP1
    Homologene
    FAMILY
  • d-isomer specific 2-hydroxyacid dehydrogenases family
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved with histone deacetylase and E2F3 in transcription repression
  • negative control of cell proliferation
  • viral replication
  • might modulate the biochemical activities of adenovirus E1A
  • playing important roles during development and oncogenesis
  • selectively down-regulates Th2 cytokines
  • ZFPM1, ZFPM2, and CTBP1 and CTBP2 are partners of GATA2, GATA3 proteins in the control of adipocyte proliferation and differentiation
  • required for the oncogenic potential of BCL3 and for its ability to inhibit UV-mediated cell apoptosis in keratinocytes
  • CTBP2 and ATXN1 were recruited to the CDH1 promoter in mammalian cells
  • able to promote the oligomerization of truncated APC through binding to the 15 amino acid repeats of truncated APC
  • CTBP1, CTBP2 are essential pro-survival proteins in neurons and their downregulation contributes significantly to neuronal apoptosis via the de-repression of pro-apoptotic genes
  • CTBP1 and CTBP2 are closely related and act as transcriptional corepressors when activated by nicotinamide adenine dinucleotide binding to their dehydrogenase domains
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homo or heterodimers of CTBP1 and CTBP2
  • CTBP2-mediated oligomerization requires both dimerization domains of truncated APC as well as CTBP2 dimerization
  • INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NAD+
    protein
  • associating to the C terminus of adenovirus E1A, CTBP1 and CTBP2
  • UNC119 is a CTBP2-interacting protein at photoreceptor ribbon synapses (can be recruited to synaptic ribbons via its interaction with CTBP2)
  • interaction of CTBPs with transcriptional regulators and/or chromatin-modifying enzymes in the cell nucleus, rather than their role in Golgi fission, which is critical for the maintenance of mitotic fidelity
  • interacted with ATXN1 (CTBP2 and ATXN1 colocalized in the nucleus of mammalian cells)
  • unexpected function of the corepressor CTBP2 as a coactivator for RAR/RXRA in RA signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to prostate cancer
    Variant & Polymorphism SNP increasing the risk of prostate cancer
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential target for therapeutic strategies for the treatment of cancer in general, and breast cancer in particular
    allergy  
    potential target for the treatment of allergic diseases
    ANIMAL & CELL MODELS