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Symbol CTBP1 contributors: mct - updated : 11-06-2015
HGNC name C-terminal binding protein 1
HGNC id 2494
Location 4p16.3      Physical location : 1.205.227 - 1.242.908
Synonym name
  • adenovirus E1A binding protein 1
  • brefeldin A-ribosylated substrate
  • Synonym symbol(s) CTP1, BARS, MGC104684, CTBP
    EC.number 1.1.1.-
    TYPE functioning gene
    STRUCTURE 37.68 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PCDH18 4q31.2-q32 protocadherin 18 LOC389255 4 similar to RSTI689 LOC152687 4p16.3 hypothetical protein LOC152687 AMBN 4q21 ameloblastin, enamel matrix protein FLJ90036 4p16.3 hypothetical protein FLJ90036 LOC391611 4 similar to Zinc finger protein 208 ZNF141 4p16.3 zinc finger protein 141 (clone pHZ-44) FLJ14297 4p16.3 hypothetical protein FLJ14297 FLJ20265 4p16.3 hypothetical protein FLJ20265 PDE6B 4p16.3 phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant) ATP5I 4p16.3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit e MYL5 4p16.3 myosin, light polypeptide 5, regulatory FLJ22269 4p16.3 hypothetical protein FLJ22269 RNF3 4p16.3 ring finger protein 3 CPLX1 4p16.3 complexin 1 GAK 4p16 cyclin G associated kinase MGC4618 4p16.3 hypothetical protein MGC4618 DGKQ 4p16.3 diacylglycerol kinase, theta 110kDa SLC26A1 4p16.3 solute carrier family 26 (sulfate transporter), member 1 IDUA 4p16.3 iduronidase, alpha-L- FGFRL1 4p16 fibroblast growth factor receptor-like 1 LOC285498 4p16.3 hypothetical protein LOC285498 LOC132969 4p16.3 similar to hornerin SPON2 4p16.3 spondin 2, extracellular matrix protein CTBP1 4p16 C-terminal binding protein 1 MGC21675 4p16.3 hypothetical protein MGC21675 MAEA 4p16.3 macrophage erythroblast attacher KIAA1530 4p16.3 KIAA1530 protein FLJ34443 4p16.3 hypothetical protein FLJ34443 HSPX153 4p16.3 HPX-153 homeobox LOC345375 4p16.3 similar to CG32656-PA LOC152877 4p16.3 similar to RIKEN cDNA 5430419M09 SLBP 4p16 stem-loop (histone) binding protein LOC92305 4p16.3 hypothetical protein BC009331 TACC3 4p16.3 transforming, acidic coiled-coil containing protein 3 FGFR3 4p16.3 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) LETM1 4p16.3 leucine zipper-EF-hand containing transmembrane protein 1 WHSC1 4p16.3 Wolf-Hirschhorn syndrome candidate 1 WHSC2 4p16.3 Wolf-Hirschhorn syndrome candidate 2 LOC389195 4 hypothetical gene supported by BC038466; BC047038 FLJ37478 4p16.3 hypothetical protein FLJ37478 POLN 4p16.3 polymerase (DNA directed) nu MGC4701 4p16.3 hypothetical protein MGC4701 MXD4 4p16.3 MAX dimerization protein 4 KIAA1643 4p16.3 KIAA1643 protein LOC339985 4p16.3 hypothetical gene supported by BC010180 RNF4 4p16.3 ring finger protein 4 C4orf8 4p16.3 chromosome 4 open reading frame 8 TNIP2 4p16.3 TNFAIP3 interacting protein 2 LOC389196 4 LOC389196 SH3BP2 4p16.3 SH3-domain binding protein 2 ADD1 4p16.3 adducin 1 (alpha) TETRAN 4p16.3 tetracycline transporter-like protein C4orf9 4p16.3 chromosome 4 open reading frame 9 GPRK2L 4p16.3 G protein-coupled receptor kinase 2-like (Drosophila) HD 4p16.3 huntingtin (Huntington disease) LOC345222 4p16.3 hypothetical gene supported by BC043530 RGS12 4p16.3 regulator of G-protein signalling 12 HGFAC 4p16.3 HGF activator FLJ33718 4p16.3 hypothetical protein FLJ33718
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2288 - 440 - 2008 18361917
    10 - 2483 - 429 - 2008 18361917
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunelymph node   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemprostate   
    cell lineage
    cell lines
    at STAGE
  • a PXDLS-binding site, involved in the interaction between CTBP1 and SIMC1
  • conjugated PhosphoP
    mono polymer homomer , heteromer , dimer
    interspecies homolog to murine Ctbp1 (98.9pc)
    homolog to C.elegans F49e10.5
    homolog to rattus Ctbp1 (98.6pc)
    intraspecies homolog to CTBP2
  • d-isomer specific 2-hydroxyacid dehydrogenases family
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
  • restricted to nuclear speckles and co-localized with GLIS2
  • LCOR and CTBP1 colocalize in nuclear bodies
  • basic FUNCTION
  • transcriptional repressor in a histone acetylase dependent or independent manner
  • playing a role during cellular proliferation, adenovirus replication and oncogenic transformation
  • negative control of cell proliferation
  • involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex
  • dehydrogenase activity
  • attenuates KLF4-mediated transcriptional activation through the physical interaction with KLF4
  • can interact with a polycomb group protein complex which participates in regulation of gene expression during development
  • acts in the nucleus as transcriptional corepressor and in the cytoplasm as regulators of Golgi apparatus fission
  • promotes cell survival through the maintenance of mitotic fidelity
  • corepressor that regulates transcription of the CYP17 gene by periodically interacting with steroidogenic factor-1 in response to ACTH signaling
  • transcriptional corepressor with tumorigenic potential that targets the promoter of the tumor suppressor gene E-cadherin
  • can recruit PNN to CTBP-associated complexes, resulting in Pnn-dependent chromatin remodeling at the E-cadherin promoter
  • is required for macropinocytic internalization and infection of ectovirus 1
  • target of PAK1 and is bifunctionally involved in membrane traffic and transcriptional repression of cell cycle, cancer, and innate immunity pathways
  • role for LCOR and CTBP1 as attenuators of progesterone-regulated transcription, suggesting that LCOR and CTBP1 can act to enhance transcription of some genes
  • central role to control the actions of many transcriptional factors, in large part, by recruitment and activation of a range of chromatin remodeling enzymes
  • transcriptional co-repressor and metabolic sensory protein, which often represses tumor suppressor genes
  • required for the ability of BCL3 to repress gene transcription, CTBP1 is also required for the oncogenic potential of BCL3 and for its ability to inhibit UV-mediated cell apoptosis in keratinocytes)
  • with TBL1XR1, are key regulators of different properties of the BCL3 oncoprotein
  • ZFPM1, ZFPM2, and CTBP1 and CTBP2 are partners of GATA2, GATA3 proteins in the control of adipocyte proliferation and differentiation
  • key transcriptional coregulator in adipose tissue
  • transcriptional repressor which plays a significant role in the regulation of cell proliferation and tumor progression
  • AMPK and CTBP1 act as energy sensors and cause cell death upon glucose deprivation
  • CTBP1, CTBP2 are essential pro-survival proteins in neurons and their downregulation contributes significantly to neuronal apoptosis via the de-repression of pro-apoptotic genes
  • potential functions and transcriptional activities of CTBP1 in the context of epithelial-mesenchymal interplay, suggesting that CTBP1 has a pathogenic role in hair follicle morphogenesis and differentiation
  • CTBP1 and CTBP2 are closely related and act as transcriptional corepressors when activated by nicotinamide adenine dinucleotide binding to their dehydrogenase domains
  • role of CTBP1, a transcriptional co-repressor enriched in presynapses and nuclei, in the activity-driven reconfiguration of gene expression in neurons
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    a component
  • homo or heterodimer of CTBP1 and CTBP2
  • RB1/RBBP8/CTBP1/E2F1 complex plays a critical role in ZNF350 transcriptional repression, and loss of this repression may contribute to cellular sensitivity of DNA damage, ultimately leading to carcinogenesis
    small molecule cofactor,
  • binds to NAD(+)/NADH and may respond to the metabolic state of the cell, thereby linking changes in nutrient levels to transcriptional outcomes
  • protein
  • corepressor interacting with KLF3, KLF12
  • the C terminus of adenovirus E1A protein, ELK3, CTIP (BCL11X) CTBP2
  • interacting with HD
  • interact with GLIS2 (repressed transcriptional activation induced by GLIS2)
  • interacting with KLF4
  • interacts with FOXP2, HDAC4, HDAC5, HDAC9, FOXP1, HIPK2, PNN, NRIP1, ZFHX1B, WIZ, EBNA3, EBNA6
  • CBX4 might coordinate multiple enzymatic activities to regulate CTBP1 function
  • represses BRCA1 transcription by binding to the E2F4 site of the BRCA1 promoter
  • ETV6 orchestrates endothelial sprouting by binding to the generic co-repressor, CTBP1
  • interaction of CTBPs with transcriptional regulators and/or chromatin-modifying enzymes in the cell nucleus, rather than their role in Golgi fission, which is critical for the maintenance of mitotic fidelity
  • CTBP1 interacts with Ikaros and modulates pituitary tumor cell survival and response to hypoxia
  • 1180 AA regions of CTBP1 are responsible for binding with AMPK, and interaction with AMPK serves as a phosphorylation target of AMPK under the condition of glucose deprivation
  • SIMC1 interacts with CTBP1 (C-terminal binding protein 1), a transcriptional co-regulator
  • CTBP1 is targeted and/or anchored to presynapses by direct interaction with the active zone scaffolding proteins BSN and PCLO
  • cell & other
    Other the level of phosphorylation appears to be regulated during the cell cycle
    phosphorylated upon DNA damage
    ADP-ribosylated when cells are exposed to Brefeldin A
    sumoylated by CBX4
    Sumoylation of CTBP1 has an effect on its subcellular localization and thus attenuates the corepressive function
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    reduction of CTBP1 expression is correlated with migratory, invasive potential of melanoma cells
    Variant & Polymorphism
    Candidate gene
    Therapy target
    cancerhead and neck 
    potential chemo preventative or therapeutic strategy for head and neck squamous cell carcinomas (HNSCCs) by blocking NADH-dependent CTBP1 activity at early stages of HNSCC carcinogenesis
    potential target for therapeutic strategies for the treatment of cancer in general, and breast cancer in particular
    potential therapeutic target in human disease