Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CTAG2 contributors: - updated : 02-11-2004
HGNC name cancer/testis antigen 2
HGNC id 2492
Location Xq28      Physical location : 153.880.245 - 153.881.853
Synonym name
  • LAGE-1 protein
  • CTL-recognized antigen on melanoma
  • Synonym symbol(s) LAGE1, CAMEL , ESO2, LAGE-1, LAGE-2b, MGC3803
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    alternative promoter
    cytosine-phosphate-guanine/HTF
    text structure two ATGs,CpG rich promoter
    MAPPING cloned Y linked N status confirmed
    Physical map
    EMD Xq28 emerin (Emery-Dreifuss muscular dystrophy) RPL10 Xq28 ribosomal protein L10 DNASE1L1 Xq28 deoxyribonuclease I-like 1 TAZ Xq28 tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) ATP6AP1 Xq28 ATPase, H+ transporting, lysosomal accessory protein 1 GDI1 Xq28 GDP dissociation inhibitor 1 DXS9928E Xq28 DNA segment on chromosome X (unique) 9928 expressed sequence PLXN3 Xq28 likely ortholog of mouse plexin 3 DXS9879E Xq28 DNA segment on chromosome X (unique) 9879 expressed sequence UBL4 Xq28 ubiquitin-like 4 SLC10A3 Xq28 solute carrier family 10 (sodium/bile acid cotransporter family), member 3 FAM3A Xq28 family with sequence similarity 3, member A G6PD Xq28 glucose-6-phosphate dehydrogenase IKBKG Xq28 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma SPCX Xq28 SPCX LAGE2A  cancer/testis antigen 1-A CTAG1 Xq28 cancer/testis antigen 1 LOC340600 Xq28 cyclic-AMP-dependent transcription factor ATF-4 pseudogene deltaNEMO Xq28 deltaNEMO CTAG2 Xq28 cancer/testis antigen 2 LOC392561 X similar to olfactory receptor MOR255-2 GAB3 Xq28 GRB2-associated binding protein 3 DKC1 Xq28 dyskeratosis congenita 1, dyskerin MPP1 Xq28 membrane protein, palmitoylated 1, 55kDa LOC158957 Xq28 hypothetical LOC158957 F8 Xq28 coagulation factor VIII, procoagulant component (hemophilia A)
    regionally located in the NEMO/LAGE cluster
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 7550 - 180 - Lethe
    - splicing 1002 21 210 - Lethe
    exon 1 joined to exon 2
    - - 680 - 109 - Aarnoudse
    - - 990 - - - -
    alternative frame starting from the second ATG
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines melanoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two glycine-rich regions
  • a hydrophobic stretch near the C-terminus
  • HOMOLOGY
    intraspecies homolog to CTAG1B
    Homologene
    FAMILY NY-ESO-1 family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION tumor antigen that may serve as a target for immunotherapy
    CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by deoxy-azacytidine in lymphoblastoic cells
    inhibited by silenced by DNA methylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS