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FLASH GENE
Symbol CTAG2 contributors: - updated : 02-11-2004
HGNC name cancer/testis antigen 2
HGNC id 2492
Location Xq28      Physical location : 153.880.245 - 153.881.853
Synonym name
  • LAGE-1 protein
  • CTL-recognized antigen on melanoma
  • Synonym symbol(s) LAGE1, CAMEL , ESO2, LAGE-1, LAGE-2b, MGC3803
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    alternative promoter
    cytosine-phosphate-guanine/HTF
    text structure two ATGs,CpG rich promoter
    MAPPING cloned Y linked N status confirmed
    regionally located in the NEMO/LAGE cluster
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 7550 - 180 - Lethe
    - splicing 1002 21 210 - Lethe
    exon 1 joined to exon 2
    - - 680 - 109 - Aarnoudse
    - - 990 - - - -
    alternative frame starting from the second ATG
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines melanoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two glycine-rich regions
  • a hydrophobic stretch near the C-terminus
  • HOMOLOGY
    intraspecies homolog to CTAG1B
    Homologene
    FAMILY NY-ESO-1 family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION tumor antigen that may serve as a target for immunotherapy
    CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by deoxy-azacytidine in lymphoblastoic cells
    inhibited by silenced by DNA methylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS