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FLASH GENE
Symbol CT55 contributors: mct - updated : 05-06-2020
HGNC name cancer/testis antigen 55
HGNC id 26047
Location Xq26.3      Physical location : -
Synonym name
  • chromosome X open reading frame 48
  • tumor antigen BJ-HCC-20
  • hypothetical protein LOC54967
  • Synonym symbol(s) BJHCC20A, FLJ20527, CXorf48
    DNA
    TYPE functioning gene
    STRUCTURE 15.29 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1441 29 264 - 2017 28862699
    5 - 2188 26.5 242 - 2017 28862699
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland    
    Endocrineadrenal gland    
    Reproductivemale systemtestis    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • CT55 functions in Colitis-associated cancer (CAC) are dependent on TNF-induced NFKB1 signaling
  • may be involved in colitis-associated colon tumorigenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mechanistically, CT55 acts as an accelerator of tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NFKB1) signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    suppresses the development of Colitis-associated cancer (CAC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • mRNA positivity of CXORF48, MAGEB6, and CRISP2 presented significant associations with recognized clinical features for poor outcome in head and neck squamous cell carcinoma (HNSCC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    could be a promising therapeutic target of leukemic stem cells (LSCs) for immunotherapy to obtain durable treatment-free remission in CML patients
    cancerdigestivecolon
    could be a novel target for CAC treatment
    ANIMAL & CELL MODELS
  • Ct55-deficient mice were resistant to CAC in a colitis-associated colon cancer model