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FLASH GENE
Symbol CSTF3 contributors: mct - updated : 19-01-2016
HGNC name cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
HGNC id 2485
Location 11p13      Physical location : 33.106.134 - 33.183.037
Synonym name CSTF 77 kDa subunit
Synonym symbol(s) CSTF-77, MGC117398, MGC43001
DNA
TYPE functioning gene
STRUCTURE 76.91 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2846 - 717 - 2013 23874216
3 - 655 - 103 - 2013 23874216
2 - 777 - 44 - 2013 23874216
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Lymphoid/Immunelymph node   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative nuclear localization signal (NLS)
  • a proline rich domain at the junction of the conserved domain II and the C terminal region
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to Drosophila suppressor of forked protein SU(b)
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • pre-mRNA polyadenylation
  • cleavage stimulation factors that combine with CSTF1 and CSTF2 to form the cleavage stimulation factor complex (CSTF)
  • the conserved intronic cleavage/polyadenylation (C/P) site of the CSTF3 gene may function as a sensor for cellular cleavage/polyadenylation (C/P) and splicing activities, controlling the homeostasis of CSTF3 and C/P activity and impacting cell proliferation and differentiation
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text polyadenylation
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CSF and of CPSF, of the 3' pre RNA
  • polyadenylation complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the C terminal domain of RNA polymerase
  • associates with the cleavage and polyadenylation specificity factor (CPSF3) (are required for the maturation of mRNA 3 prime ends in the cell nucleus, with CDC73) (Rozenblatt-Rosen 2009)
  • Hinge domain is necessary for CSTF2 interaction with CSTF3 and consequent nuclear localization, suggesting that nuclear import of a preformed CSTF complex is an essential step in polyadenylation
  • interaction with the transcriptional coa
  • interactions between CSTF2/CSTF2T and CSTF3 are important for the maintenance of stoichiometric nuclear levels of the CSTF complex components and for their intracellular localization, stability, and function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS