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FLASH GENE
Symbol CSTF3 contributors: mct - updated : 19-01-2016
HGNC name cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
HGNC id 2485
Location 11p13      Physical location : 33.106.134 - 33.183.037
Synonym name CSTF 77 kDa subunit
Synonym symbol(s) CSTF-77, MGC117398, MGC43001
DNA
TYPE functioning gene
STRUCTURE 76.91 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
C11orf8 11p13 chromosome 11 open reading frame 8 LOC387759 11 LOC387759 FLJ46154 11p14.1 FLJ46154 protein LOC341019 HCP25 11p13 cytochrome c, somatic pseudogene LOC120526 11p14.1 hypothetical protein LOC120526 FLJ25059 11p14.1 hypothetical protein FLJ25059 ELP4 11p13 elongation protein 4 homolog (S. cerevisiae) PAX6 11p13 paired box gene 6 (aniridia, keratitis) RCN1 11p13 reticulocalbin 1, EF-hand calcium binding domain LOC390105 11 similar to RIKEN cDNA 0610012H03 WT1 11p13 Wilms tumor 1 WIT-1 11p13 Wilms tumor associated protein LOC387760 11 LOC387760 GA17 11p13 LOC387760 RPL34P2 11p13 ribosomal protein L34 pseudogene 2 TMG4 11p13 transmembrane gamma-carboxyglutamic acid protein 4 FLJ21924 11p13 hypothetical protein FLJ21924 LOC91614 11p13 novel 58.3 KDA protein FLJ11336 11p13 hypothetical protein FLJ11336 PIGCP1 11p13-p12 phosphatidylinositol glycan, class C, pseudogene 1 CSTF3 11p13 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa LOC390107 11 similar to ribosomal protein S24 HIPK3 11p13 homeodomain interacting protein kinase 3 G2 11p13 G2 protein MGC34830 11p13 hypothetical protein MGC34830 CD59 11p13 CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) FBXO3 11p12 F-box only protein 3 LOC390108 11 similar to hypothetical protein MGC40611 LMO2 11p13 LIM domain only 2 (rhombotin-like 1) M11S1 11p13 membrane component, chromosome 11, surface marker 1 FLJ10774 11p13 N-acetyltransferase-like protein ABTB2 11p13 ankyrin repeat and BTB (POZ) domain containing 2 CAT 11p13 catalase ELF5 11p15-p13 E74-like factor 5 (ets domain transcription factor) EHF 11p12 ets homologous factor MMRP19 11p13 likely ortholog of mouse monocyte macrophage 19 PDHX 11p13 pyruvate dehydrogenase complex, component X CD44 11p13 CD44 antigen (homing function and Indian blood group system) SLC1A2 11p13-p12 solute carrier family 1 (glial high affinity glutamate transporter), member 2 DKFZP586H2123 11p13 DKFZP586H2123 protein FJX1 11p13 four jointed box 1 (Drosophila) TRIM44 11p12-14 tripartite motif-containing 44
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2846 - 717 - 2013 23874216
3 - 655 - 103 - 2013 23874216
2 - 777 - 44 - 2013 23874216
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Lymphoid/Immunelymph node   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative nuclear localization signal (NLS)
  • a proline rich domain at the junction of the conserved domain II and the C terminal region
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to Drosophila suppressor of forked protein SU(b)
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • pre-mRNA polyadenylation
  • cleavage stimulation factors that combine with CSTF1 and CSTF2 to form the cleavage stimulation factor complex (CSTF)
  • the conserved intronic cleavage/polyadenylation (C/P) site of the CSTF3 gene may function as a sensor for cellular cleavage/polyadenylation (C/P) and splicing activities, controlling the homeostasis of CSTF3 and C/P activity and impacting cell proliferation and differentiation
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text polyadenylation
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CSF and of CPSF, of the 3' pre RNA
  • polyadenylation complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the C terminal domain of RNA polymerase
  • associates with the cleavage and polyadenylation specificity factor (CPSF3) (are required for the maturation of mRNA 3 prime ends in the cell nucleus, with CDC73) (Rozenblatt-Rosen 2009)
  • Hinge domain is necessary for CSTF2 interaction with CSTF3 and consequent nuclear localization, suggesting that nuclear import of a preformed CSTF complex is an essential step in polyadenylation
  • interaction with the transcriptional coa
  • interactions between CSTF2/CSTF2T and CSTF3 are important for the maintenance of stoichiometric nuclear levels of the CSTF complex components and for their intracellular localization, stability, and function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS