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FLASH GENE
Symbol CSTF1 contributors: npt/mct - updated : 27/11/2008
HGNC name cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
HGNC id 2483
Location 20q13.31      Physical location : 54.967.426 - 54.979.582
Synonym name
  • CSTF 50 kDa subunit
  • CF-1 50 kDa subunit
  • Synonym symbol(s) CstFp50, CstF-50
    DNA
    TYPE functioning gene
    STRUCTURE 12.15 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D20S183 - D20S913 - D20S120 - D20S832 - [D20S102 - BMP7 - PCK1 ] - GNAS - D20S171 - EDN3 - D20S173 - qter
    Authors Gene Map (98)
    Text [CSTF1 ]
    RNA
    TRANSCRIPTS type messenger
    text Variants 1, 2 and 3 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2295 48 431 - Ruegsegger (1996)
    6 - 2323 - 431 - Ruegsegger (1996)
    6 - 2292 48 431 - Ruegsegger (1996)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineadrenal gland   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a transducin repeat in which an approximately 44AA long sequence is repeated seven times
  • HOMOLOGY
    intraspecies homolog to G protein beta-subunit
    Homologene
    FAMILY
  • Trp-Asp (WD) repeat proteins proteins family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • invoved in pre-RNA polyadenylation
  • required for the specific cleavage and polyadenylation of pre-mRNA
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text mRNA cleavage and processing
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 3' pre-RNA polyadenylation complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BARD1
  • interacting with the C terminal domain of RNA polymerase 2
  • with poly(A) polymerase (PAP) had no detectable effect on the binding of CPSF6
  • to pre-mRNA
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS