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FLASH GENE
Symbol CSTF1 contributors: npt/mct - updated : 27/11/2008
HGNC name cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
HGNC id 2483
Location 20q13.31      Physical location : 54.967.426 - 54.979.582
Synonym name
  • CSTF 50 kDa subunit
  • CF-1 50 kDa subunit
  • Synonym symbol(s) CstFp50, CstF-50
    DNA
    TYPE functioning gene
    STRUCTURE 12.15 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D20S183 - D20S913 - D20S120 - D20S832 - [D20S102 - BMP7 - PCK1 ] - GNAS - D20S171 - EDN3 - D20S173 - qter
    Authors Gene Map (98)
    Text [CSTF1 ]
    Physical map
    RPL12P4 20q13.2 ribosomal protein L12 pseudogene 4 CBLNL1 20q13.13-q13.33 cerebellin precursor-like 1 MC3R 20q13.2-q13.3 melanocortin 3 receptor C20orf108 20q13.2 chromosome 20 open reading frame 108 STK6 20q13.31 serine/threonine kinase 6 CSTF1 20q13.2-q13.3 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa C20orf32 20q13.31 chromosome 20 open reading frame 32 RPL39P 20q13.2 ribosomal protein L39 pseudogene C20orf43 20q13.31 chromosome 20 open reading frame 43 C20orf106 20q13.2 chromosome 20 open reading frame 106 LOC388799 20 similar to dJ1153D9.4 (novel protein) RPS4L 20q13.2 ribosomal protein S4-like TFAP2C 20q13.2 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) PTMAP6 20 prothymosin, alpha pseudogene 6 LOC388800 20 LOC388800 LOC339583 20q13.31 hypothetical LOC339583 BMP7 20q13.2 bone morphogenetic protein 7 (osteogenic protein 1) LOC284754 20q13.31 hypothetical gene supported by BC037891 SPO11 20q13.2-q13.3 SPO11 meiotic protein covalently bound to DSB-like (S. cerevisiae) RAE1 20q13.31 RAE1 RNA export 1 homolog (S. pombe) RNPC1 20q13.31 RNA-binding region (RNP1, RRM) containing 1 LOC149767 20q13.31 similar to dJ579F20.1 (high-mobility group (nonhistone chromosomal) protein 1-like 1) CTCFL 20q13.31 CCCTC-binding factor (zinc finger protein)-like PCK1 20q13.3 phosphoenolpyruvate carboxykinase 1 (soluble)
    RNA
    TRANSCRIPTS type messenger
    text Variants 1, 2 and 3 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2295 48 431 - Ruegsegger (1996)
    6 - 2323 - 431 - Ruegsegger (1996)
    6 - 2292 48 431 - Ruegsegger (1996)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineadrenal gland   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a transducin repeat in which an approximately 44AA long sequence is repeated seven times
  • HOMOLOGY
    intraspecies homolog to G protein beta-subunit
    Homologene
    FAMILY
  • Trp-Asp (WD) repeat proteins proteins family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • invoved in pre-RNA polyadenylation
  • required for the specific cleavage and polyadenylation of pre-mRNA
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text mRNA cleavage and processing
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 3' pre-RNA polyadenylation complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BARD1
  • interacting with the C terminal domain of RNA polymerase 2
  • with poly(A) polymerase (PAP) had no detectable effect on the binding of CPSF6
  • to pre-mRNA
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS