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FLASH GENE
Symbol CST7 contributors: mct - updated : 22-05-2008
HGNC name cystatin F (leukocystatin)
HGNC id 2479
Location 20p11.22-p11.21      Physical location : 24.929.865 - 24.940.561
Synonym name
  • cystatin-like metastasis associated protein
  • leukocystatin
  • Synonym symbol(s) CMAP
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 10.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure a unique site for C/EBPalpha
    MAPPING cloned Y linked N status provisional
    Map pter - FKBP1A - CDC25B - CHED1 - PCNA - CST7 - PLCB4 - ZNF133 - CST1 - NNAT - EIF6 - cen
    Authors Morita (00)
    regionally located upstream and closely linked to C20orf3, clustered in a space of 900kb
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 928 18 167 - -
    EXPRESSION
    Type restricted
    constitutive ofselectively in immune cells
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage hematopoietic cells
    cell lines T cells and meyeloid cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • intracellular and transmembrane domain two cystine bridges, possible protein linkage cysteine-cysteine
  • conjugated GlycoP
    mono polymer homomer , dimer
    isoforms Precursor inactive disulphide-linked dimeric precursor
    HOMOLOGY
    Homologene
    FAMILY
  • cystatin superfamily
  • cystatin type 2 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    text
  • secreted but can be targeted to the endocytic pathway under specific conditions and its C-terminal domain might contribute to this event by addition of multiple amino acids
  • basic FUNCTION
  • protease inhibitor
  • may regulate diverse immune cell effector functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cathepsin C is its major target
  • cell & other
    REGULATION
    inhibited by proteolysis in the endocytic pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in liver metastatic tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene approach to the diagnosis and/or prevention of liver metastasis of cancer
    Marker
    Therapy target
    ANIMAL & CELL MODELS