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FLASH GENE
Symbol CSRP3 contributors: SGE/npt - updated : 21/10/2008
HGNC name cysteine and glycine-rich protein 3 (cardiac LIM protein)
HGNC id 2472
Corresponding disease
CMD1M cardiomyopathy, dilated 1M
Location 11p15.1      Physical location : 19.203.577 - 19.223.589
Synonym name
  • muscle LIM protein
  • cardiac LIM domain protein
  • LIM domain only 4
  • cysteine-rich protein 3
  • Synonym symbol(s) CLP, MLP, CRP3, LMO4, CSR3, MGC14488, MGC61993
    DNA
    TYPE functioning gene
    STRUCTURE 20.02 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1341 21 194 - Zheng (2008)
    6 - 1286 21 194 - Zheng (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Reproductivemale systemprostate  lowly
    Respiratorylung   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac highly
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N-terminal cysteine-rich LIM/double finger motifs (LIM domains)
  • a glycine-rich repeat (for the ACTN binding)
  • N-terminal half mediated activation of NPPA
  • HOMOLOGY
    interspecies homolog to murine Csrp3
    Homologene
    FAMILY
  • CSRF family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • sarcolemma
  • colocalizes with GLRX3 in the Z-disc
  • basic FUNCTION
  • essential nuclear regulator of myogenic differentiation
  • likely involved in the determination of cell lineage and regulation of cell differentiation
  • having crucial functions in the downstream signal transduction in response to mechanical stress and could involve improper response to myocardial stress sensing
  • actin-binding protein that increases actin cytoskeleton stability by promoting bundling of actin filaments
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • cytosolic component of cardiomyocytes and not tightly anchored to sarcomeric structures
  • forming a complex with CFL2 that is directly invovled in sarcomere dysfunction and disase, due to its role in regulating CFL2-dependent F actin depolymerization (Papalouka 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to TCAP (Z disc MLP/TCAP complex, key component of the cardiomyocytes stretch sensor machinery)
  • ACTN2
  • modulating the transcriptional activity of HEN1
  • interacting with TCAP (Knoll (2002)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMD1M
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS