Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CSRP3 contributors: SGE/npt - updated : 21/10/2008
HGNC name cysteine and glycine-rich protein 3 (cardiac LIM protein)
HGNC id 2472
Corresponding disease
CMD1M cardiomyopathy, dilated 1M
Location 11p15.1      Physical location : 19.203.577 - 19.223.589
Synonym name
  • muscle LIM protein
  • cardiac LIM domain protein
  • LIM domain only 4
  • cysteine-rich protein 3
  • Synonym symbol(s) CLP, MLP, CRP3, LMO4, CSR3, MGC14488, MGC61993
    DNA
    TYPE functioning gene
    STRUCTURE 20.02 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MRGX3 11p15.1 G protein-coupled receptor MRGX3 MRGX4 11p15.1 G protein-coupled receptor MRGX4 SAA4 11p15.1-p14.3 serum amyloid A4, constitutive SAA2 11p15.1-p14.3 serum amyloid A2 FAM10A5 11p15.1 family with sequence similarity 10, member A5 SAA1 11p15.1-p14.3 serum amyloid A1 HPS5 11p14 Hermansky-Pudlak syndrome 5 GTF2H1 11p15.1-p14 general transcription factor IIH, polypeptide 1, 62kDa LDHA 11p15.1-p14.3 lactate dehydrogenase A LDHC 11p15.1-p14.3 lactate dehydrogenase C MGC23940 11p15.1 hypothetical protein MGC23940 TSG101 11p15.2-p15.1 tumor susceptibility gene 101 UEV3 11p15.1 ubiquitin-conjugating enzyme E2-like LOC390097 11 similar to CGI-64 protein FLJ39441 11p15.1 hypothetical protein FLJ39441 FLJ90119 11p15.1 hypothetical protein FLJ90119 FLJ37794 11p15.1 hypothetical protein FLJ37794 PTPN5 11p15.2-p15.1 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) LOC390098 11 similar to G protein-coupled receptor MRGX1 LOC390099 11 similar to G protein-coupled receptor SNSR2 MRGX1 11p15.1 G protein-coupled receptor MRGX1 LOC390100 11 similar to G protein-coupled receptor MRGX3 LOC390101 11 similar to G protein-coupled receptor SNSR1 MRGX2 11p15.1 G protein-coupled receptor MRGX2 HIP14L 11p15.1 G protein-coupled receptor MRGX2 CSRP3 11p15.1 cysteine and glycine-rich protein 3 (cardiac LIM protein) FLJ23311 11p15.1 FLJ23311 protein LOC390102 11 similar to Proliferating cell nuclear antigen (PCNA) (Cyclin) NAV2 11p15.1 neuron navigator 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1341 21 194 - Zheng (2008)
    6 - 1286 21 194 - Zheng (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Reproductivemale systemprostate  lowly
    Respiratorylung   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac highly
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N-terminal cysteine-rich LIM/double finger motifs (LIM domains)
  • a glycine-rich repeat (for the ACTN binding)
  • N-terminal half mediated activation of NPPA
  • HOMOLOGY
    interspecies homolog to murine Csrp3
    Homologene
    FAMILY
  • CSRF family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • sarcolemma
  • colocalizes with GLRX3 in the Z-disc
  • basic FUNCTION
  • essential nuclear regulator of myogenic differentiation
  • likely involved in the determination of cell lineage and regulation of cell differentiation
  • having crucial functions in the downstream signal transduction in response to mechanical stress and could involve improper response to myocardial stress sensing
  • actin-binding protein that increases actin cytoskeleton stability by promoting bundling of actin filaments
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • cytosolic component of cardiomyocytes and not tightly anchored to sarcomeric structures
  • forming a complex with CFL2 that is directly invovled in sarcomere dysfunction and disase, due to its role in regulating CFL2-dependent F actin depolymerization (Papalouka 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to TCAP (Z disc MLP/TCAP complex, key component of the cardiomyocytes stretch sensor machinery)
  • ACTN2
  • modulating the transcriptional activity of HEN1
  • interacting with TCAP (Knoll (2002)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMD1M
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS