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FLASH GENE
Symbol CSRNP1 contributors: SGE/npt - updated : 03-12-2009
HGNC name cysteine-serine-rich nuclear protein 1
HGNC id 14300
Location 3p22.2      Physical location : 39.183.343 - 39.195.102
Synonym name
  • AXIN1 induced gene
  • AXIN1 up-regulated 1
  • TGF-beta-induced apoptosis protein
  • Synonym symbol(s) URAX1, FAM130B, TAIP-3, AXUD1, DKFZp566F164, CSRNP-1
    DNA
    TYPE functioning gene
    STRUCTURE 11.76 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3188 63 589 - Ishiguro (2001)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Reproductivefemale systemplacenta  highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Csrnp1 (73.9pc)
    homolog to murine Csrnp1 (75.3pc)
    Homologene
    FAMILY
  • AXUD1 family (cysteine- serine-rich nuclear proteins family)
  • CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having transcriptional activator activity
  • may play a role in apoptosismay be a tumor suppressor
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the consensus sequence 5'-AGAGTG-3'
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by elevated levels of axin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lung, kidney, liver and colon cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS