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FLASH GENE
Symbol CSPG5 contributors: mct/ - updated : 05-04-2006
HGNC name chondroitin sulfate proteoglycan 5 (neuroglycan C)
HGNC id 2467
Location 3p21.31      Physical location : 47.603.728 - 47.620.359
Synonym name
  • neuroglycan, neural transmembrane chondroitin sulfate proteoglycan, brain specific
  • sixth member (neuregulin-6) of the neuregulin family
  • acidic leucine-rich EGF-like domain-containing brain protein
  • Synonym symbol(s) NGC, CALEB, NRG6, MGC44034
    DNA
    TYPE functioning gene
    STRUCTURE 16.63 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2175 54.3 539 - -
    EXPRESSION
    Rna function mRNA were expressed in the ganglion cell layer, the inner nuclear layer, and at the outer limiting membrane of retina, and in retinal pigment epithelium cells (Escher 2008)
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Nervousbrain   predominantly
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal signal sequence
  • a chondroitin sulfate-attachment domain
  • an acidic aminoacid cluster
  • an EGF-like extracellular domain
  • a transmembrane domain
  • a cytoplasmic tail
  • an extracellular domain with three potential glycosylation sites
  • HOMOLOGY
    interspecies homolog to murine Cspg5
    Homologene
    FAMILY
  • epidermal growth factor protein family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • structural protein of neural transmembrane
  • playing a role in differential adhesion and synaptogenesis of the climbing and parallele fibers with the Purkinge cell dendrites
  • playing an important role in neurite formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text formation of neural network in retinal development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to the extracellular matrix proteins tenascin-R and tenascin-C
  • interacts with the Golgi-associated protein GOPC(this interaction may play a role in the intracellular transport of CSPG5)
  • transactivating ERBB2, ligand for ERBB3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS