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FLASH GENE
Symbol CSNK2A2 contributors: mct - updated : 09-11-2014
HGNC name casein kinase 2, alpha prime polypeptide
HGNC id 2459
Location 16q21      Physical location : 58.191.815 - 58.231.782
Synonym name
  • CK II alpha'
  • casein kinase II subunit alpha'
  • Synonym symbol(s) CK2A3, CK2A2, CSNK2A1, CK2
    EC.number 2.7.1.37/2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 39.97 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1674 - 350 - 2001 11239457
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivemouthtongue  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage late stages of spermatogenesis
    cell lines
    fluid/secretion sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminus required for mitotic spindle localization
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to bovine csnk2a prime
    ortholog to murine Csnk2a2
    Homologene
    FAMILY ser/thr family of protein kinases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text localizes to the mitotic spindle in a phosphorylation-dependent manner
    basic FUNCTION
  • involved in regulation of cell growth
  • participating in WNT signaling
  • CSNK2A1 and PRPF3 are absolutely necessary for an efficient splicing whereas CSNK2A2 seems to be dispensable
  • involved, among a wide variety of cellular processes, in the maintenance of mammalian cell morphology and cell polarity
  • protects against ionizing radiation-induced apoptosis partly by phosphorylating and activating SIRT1
  • CSNK2A1, CSNK2A2 and microtubules control axon initial segment formation
  • with CSNK2A1, plays an important role in regulating nuclear ERK activities
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component a heterotetramer (2A,2B) complexing with the FACT elongation transcription factor made of SSRP1 and FACTP140
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • regulator of NKX3-1 in prostate tumor cells
  • KIF5C is a new binding partner for CSNK2A2, CSNK2A1 but KIF5C preferentially bound to CSNK2A2
  • its phosphorylation facilitates binding to the peptidyl-prolyl isomerase PIN1, which is required for CSNK2A2 mitotic spindle localization
  • repair function of PNKP is facilitated by its binding to the scaffold protein XRCC1, and phosphorylation of XRCC1 by CSNK2A2 at several consensus sites enables PNKP binding and recruitment to DNA damage
  • CSNK2A1, CSNK2A2-dependent phosphorylation of TOMM22 is a critical switch for mitophagy and reveal CSNK2A-dependent physiological implications on metabolism, muscle integrity and behavior
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    critically contributes to increased presynaptic and postsynaptic NMDAR activity in the paraventricular nucleus and elevated sympathetic vasomotor tone in essential hypertension
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    globozoospermia in mice lacking C1nk2A2