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FLASH GENE

Symbol

CSNK1G1

contributors: shn - updated : 13-10-2012

HGNC name	casein kinase 1, gamma 1
HGNC id	2454

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q22.31      Physical location : 64.457.717 - 64.648.442
Synonym name	CKI-gamma 1
	casein kinase I isoform gamma-1
Synonym symbol(s)	CK1gamma1
EC.number	2.7.1.-

DNA

TYPE	functioning gene
STRUCTURE	190.27 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D15S993 - D15S1018 - CSNK1G1 - D15S1009 - D15S1507 - qter

RNA

TRANSCRIPTS	type	messenger

text	hCK1 gamma1S encode a polypeptide consisting of 393 amino acids predominantly present in the testis PMID:11124537

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022048 11 splicing 8163 NP_071331 - 422 - - 11124537 CK1 gamma1L

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Homo sapiens Digestive intestine large intestine colon   moderately Homo sapiens   intestine small intestine     moderately Homo sapiens   liver       moderately Homo sapiens   stomach       moderately Homo sapiens Lymphoid/Immune spleen       moderately Homo sapiens Nervous brain       moderately Homo sapiens Reproductive female system placenta     moderately Homo sapiens   male system testis     highly Homo sapiens Respiratory lung       moderately Homo sapiens Urinary kidney       moderately Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   moderately Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a kinase domain
	a C terminal region divided into two structural domains
	a specific proximal highly basic
	a most terminal motif common to the L isoform and Rcsk1

conjugated

PhosphoP

mono polymer

monomer

isoforms

Precursor

HOMOLOGY

interspecies	ortholog to Csnk1g1, Rattus norvegicus
	ortholog to Csnk1g1, Mus musculus
	ortholog to csnk1g1, danio rerio
	ortholog to CSNK1G1, Pan troglodytes

Homologene

FAMILY

Ser/Thr protein kinase family, casein kinase I subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	involved in growth and morphogenesis of eukaryotic cells
	participating in Wnt signaling by phosphorylating LRP6 and mediating the recruitment of axin
	is a novel component of checkpoint responses that controls the interaction of a key checkpoint effector kinase with its cognate mediator protein
	phosphorylates the CHEK1-activating domain of Claspin

CELLULAR PROCESS	cell life, differentiation
	cell life, proliferation/growth
	protein

PHYSIOLOGICAL PROCESS

text	growth and morphogenesis of eukaryotic cells

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

cell & other

REGULATION

Other

regulated by autophosphorylation

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

depletion of CSNK1G1 from human cells by siRNA results in dramatically diminished phosphorylation of Claspin and cells display impaired activation of Chk1 and resultant checkpoint defects