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FLASH GENE
Symbol CSNK1E contributors: - updated : 22-03-2007
HGNC name casein kinase 1, epsilon
HGNC id 2453
Location 22q13.1      Physical location : 38.686.697 - 38.714.089
Synonym name serine threonine kinase isoform E
Synonym symbol(s) HCKIE
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 27.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
HRIHFB2122 22q13.1 chromosome 22 open reading frame 2 H1F0 22q13.1 H1 histone family, member 0 GCAT 22q13.1 glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A ligase) GALR3 22q13.1 galanin receptor 3 LOC129138 22q13.1 hypothetical protein BC014641 EIF3S6IP 22q12-q13 eukaryotic translation initiation factor 3, subunit 6 interacting protein MIRAB13 22q13.1-q13.2 molecule interacting with Rab13 C22orf23 22q13.1 chromosome 22 open reading frame 23 POLR2F 22q13.1 polymerase (RNA) II (DNA directed) polypeptide F SOX10 22q13.1 SRY (sex determining region Y)-box 10 LOC388899 22 LOC388899 PRKCABP 22q13.1 protein kinase C, alpha binding protein SLC16A8 22q12.3-q13.2 solute carrier 16 (monocarboxylic acid transporters), member 8 FLJ22582 22q13.1 hypothetical protein FLJ22582 PLA2G6 22q13.1-q13.32 phospholipase A2, group VI (cytosolic, calcium-independent) MAFF 22q13.1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) C22orf5 22q12 chromosome 22 open reading frame 5 CSNK1E 22q13.1 casein kinase 1, epsilon KCNJ4 22q13.1 potassium inwardly-rectifying channel, subfamily J, member 4 KDELR3 22q13.1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 DDX17 22q13.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 DMC1 22q13.1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) LOC388900 22 LOC388900 TOMM22 22q12-q13 translocase of outer mitochondrial membrane 22 homolog (yeast) C22orf2 22q12 chromosome 22 open reading frame 2 KIAA0063 22q13.1 chromosome 22 open reading frame 2 GTPBP1 22q13.1 GTP binding protein 1 UNC84B 22q13.1-q13.3 unc-84 homolog B (C. elegans) DNAL4 22q13.1 dynein, axonemal, light polypeptide 4 LOC388901 22 LOC388901
RNA
TRANSCRIPTS type messenger
text both variants 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2820 47.2 416 - -
- splicing 2670 47.2 416 - -
  • differing in the 5' UTR compared to variant 1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     mouth   highly
     pancreas exocrine   moderately
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Nervousnerve   highly
    Reproductivefemale systemplacenta  moderately
     female systemuteruscervix predominantly
    Respiratorylung   moderately
    Skin/Tegumentskin   highly
    Visualeye   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • a protein kinase domain
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to chimpanzee CSNK1E (96.7 pc)
    homolog to rattus Csnk1e (99.3 pc)
    homolog to murine Csnk1e (98.8 pc)
    homolog to chicken CSNK1E (95.7 pc)
    intraspecies homolog to CSNKP
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • casein kinase I subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • can phosphorylate a large number of proteins, like DVL1
  • participating in Wnt signaling
  • may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2
  • retaining PER1 in the cytoplasm
  • inhibiting cytokine-induced granuloytic differentiation
  • CELLULAR PROCESS nucleotide, repair, base excision repair
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS circadian , development
    text putatively involved in DNA repair throught excision and recombination
    PATHWAY
    metabolism
    signaling signal transduction
    putatively involved in generation of complete dorsal axis and induction of genes that are direct targets of WWT signals
    a component
  • autophosphorylated
  • component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting directly with PER1 and PER2 which may lead to their degradation
  • interacting with SOCS3
  • cell & other
    REGULATION
    inhibited by autoinhibition relieved by phosphatases and limited proteolysis
    Other down-regulated during granulocytic differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target for pharmaceutical compounds influencing circadian rhythms, sleep, and jet lag, as well as other physiologic and metabolic processes under circadian regulation (Lowrey, 2000)
    ANIMAL & CELL MODELS
    mammalian circadian mutation tau