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FLASH GENE
Symbol CSNK1A1 contributors: mct - updated : 19-10-2011
HGNC name casein kinase 1, alpha 1
HGNC id 2451
Location 13q13      Physical location : 148.874.844 - 148.931.007
Synonym name
  • serine threonine kinase isoform A1
  • down-regulated in lung cancer
  • Synonym symbol(s) CK1A, CK1, HLCDGP1, CK1alphaLS
    EC.number 2.7.1.37/2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 56.16 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text alternative splicing of exons encoding either the L-insert located within the catalytic domain or the S-insert located at the C terminus of the protein (PMID: 20696773)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3065
    11 - 3149 - 365 - 1995 7797465
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • S-insert located at the C terminus
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY serine/threonine protein kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text cell surface receptor linked
    basic FUNCTION
  • casein kinase 1, catalytic unit alpha 1, involved in the regulation of the G1-checkpoint at the cyclin-dependent kinase inhibitor CDKN1A
  • another kinase that regulates RIPK1 function in NF-kappaB activation
  • plays a major role in the phosphorylation of TP53 at threonine residue (Thr18) within the Mdm2/4-binding domain
  • functions as a conditionally essential malignancy gene-a member of a new class of potential cancer therapeutic targets
  • regulates several fundamental cellular processes including proliferation and differentiation
  • nuclear form playing a critical role in vascular cell proliferation, cellular activation, and hydrogen peroxide-mediated mitogenic signal transduction
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS development
    text putatively involved in generation of complete dorsal axes and induction of genes that are direct targets of WNT signals
    PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
    sphingolipid metabolism, capable of mediating G protein coupled receptor (GPCR) phosphorylation
    a component CSNK1A1 and MDM2 form a stable complex suggesting that the MDM2/CSNK1A1 complex is a component of a genetic pathway that co-regulates the stability of the TP53 and E2F-1 transcription factors
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • preferentially acidic proteins, broadly specificity
  • FADD-CSNK1A1 association regulates the subcellular localization of FADD, and phosphorylated FADD was found to colocalize with CSNK1A1 on the spindle poles in metaphase
  • interacted with and phosphorylated RIPK1 at the intermediate domain
  • interacts with endogenous TP53 and PML, and this interaction is enhanced by genotoxic stress
  • phosphorylates RHOB in vitro but not RhoA or RhoC
  • major IFNAR1 kinase that confers basal turnover of IFNAR1 and cooperates with ER stress stimuli to mediate phosphorylation-dependent degradation of IFNAR1
  • dynamically associates with the CBM (CARD11, the adaptor BCL10 and the paracaspase MALT1) complex on T-cell-receptor (TCR) engagement to participate in cytokine production and lymphocyte proliferation
  • stably associates with MDM4, stimulates MDM4-TP53 binding, and cooperates with MDM4 to inactivate TP53
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in DMD with milder phenotype
    constitutional       gain of function
    of CSNK1A1 results in accumulation of MDM2 and decreased TP53 activity, and resistance to apoptosis induced by DNA damaging agents
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS