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Symbol CSK contributors: mct/ - updated : 14-03-2012
HGNC name c-src tyrosine kinase
HGNC id 2444
Location 15q24.2      Physical location : 75.074.424 - 75.095.539
Synonym name protein-tyrosine kinase CYL
Synonym symbol(s) MGC117393, c-Src
TYPE functioning gene
STRUCTURE 21.12 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
B7H3 15q23-q24 B7 homolog 3 LOC388135 15 similar to RIKEN cDNA 6030419C18 gene MGC34741 15q22.33 hypothetical protein MGC34741 LOXL1 15q22 lysyl oxidase-like 1 STOML1 15q22 stomatin (EPB72)-like 1 PML 15q22 promyelocytic leukemia LOC390604 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC342096 15q22.33 similar to Golgi autoantigen, golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein) KIAA1465 15q22.33 KIAA1465 protein ISLR 15q23-q24 immunoglobulin superfamily containing leucine-rich repeat FLJ12541 15q22.33 stimulated by retinoic acid gene 6 LOC338951 15q22.33 hypothetical LOC338951 FLJ32855 15q23 hypothetical protein FLJ32855 CYP11A1 15q23-q24 cytochrome P450, family 11, subfamily A, polypeptide 1 SEMA7A 15q22.3-q23 sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A MGC14421 DRIL2 15q24 sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A CLK3 15q24 CDC-like kinase 3 FLJ21128 15q23 hypothetical protein FLJ21128 CYP1A1 15q22-q24 cytochrome P450, family 1, subfamily A, polypeptide 1 CYP1A2 15q22-q24 cytochrome P450, family 1, subfamily A, polypeptide 2 CSK 15q23-q25 c-src tyrosine kinase LMAN1L 15q22-23 lectin, mannose-binding, 1 like DKFZP434C131 15q23 DKFZP434C131 protein SCAMP2 15q23-q25 secretory carrier membrane protein 2 MPI 15q22-qter mannose phosphate isomerase FLJ00005 COX5A 15q25 cytochrome c oxidase subunit Va Rpp25 15q23 RNase P protein subunit p25 SCAMP5 15q22.33 RNase P protein subunit p25 MDS018 15q23 hypothetical protein MDS018 LOC390605 15 similar to stromal cell-derived factor 2 precursor DKFZP434H132 15q23 DKFZP434H132 protein LOC390606 15 similar to nucleolar phosphoprotein Nopp34 LOC388136 15 LOC388136 LOC388137 15 similar to Golgi autoantigen, golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein) LOC390607 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC145801 15q23 similar to Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines) FLJ20452 15q23 hypothetical protein FLJ20452 NEIL1 15q23 nei endonuclease VIII-like 1 (E. coli) MAN2C1 15q11-q13 mannosidase, alpha, class 2C, member 1 SIN3A 15q24 SIN3 homolog A, transcriptional regulator (yeast) PTPN9 15q22.33 protein tyrosine phosphatase, non-receptor type 9 RNUT1 15q22.33 RNA, U transporter 1 C15orf12 15q24 chromosome 15 open reading frame 12 MGC32065 15q23 hypothetical protein MGC32065 CSPG4 15q23 chondroitin sulfate proteoglycan 4 (melanoma-associated)
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2236 50.6 450 - 2005 15890649
13 - 2755 50.6 450 - 2005 15890649
Type ubiquitous
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Lymphoid/Immunespleen   highly
 tonsils   highly
Skin/Tegumentskin   highly
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
Skeletonosteoclast Homo sapiens
cell lineage hematopoietic cells
cell lines
fluid/secretion blood, lymph
  • a N terminal regulatory region containing SH3, SH2 and SRC homology domains, that may bind to different phosphoproteins, providing a basis for different cellular functions for CSK and MATK (Ayrapetov 2005)
  • a catalytic protein kinase domain
  • C-terminal specifically phosphorylates Src family kinases on a C-terminal Tyr residue, which down-regulates their activities, and SH2 domain contains a unique disulfide bond that is not present in other known SH2 domains
  • conjugated ubiquitinated
    mono polymer homomer , dimer
  • Tyr protein kinase family, CSK subfamily
  • C-terminal Src kinase (Csk) family of protein tyrosine kinases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • specifically phosphorylating Tyr-504 on LCK, which acts as a negative regulatory site
  • additional player in the regulation of the immune system by ITIM-bearing receptors
  • suppression of its activity stimulates muscle differentiation by activating MAPK14 uni-directionally
  • essential regulator of podosome structure, dynamics and organization
  • serves to maintain the constancy of baseline excitatory synaptic transmission by inhibiting Src kinase-dependent synaptic plasticity in the hippocampus
  • potential role for PAG1 as a suppressor of CSK-mediated tumor progression
  • mediate the mitogenic response to PDGF in fibroblasts
  • plays an indispensable role in ruffled border formation and bone resorption and is constitutively active in osteoclasts
  • CSK and transcription factor NFKB are considered crucial components required for normal osteoclastogenesis
  • CELLULAR PROCESS cell cycle
    a component
  • part of a signaling complex with PTK2B, LPXN, and PTPN12 to regulate migration of prostate cancer cells
  • forms homodimers through interactions mediated by the SH3 domain in a manner that buries the recognition surface for SH3 ligands
    small molecule
  • tyrosine kinase, non receptor type PTPN8
  • interacting by its proline rich domain to the SH3 domain of CSK
  • interacts with phosphorylated SIT1, PAG1 and LIME1
  • phosphorylated LAIR1 bound CSK (interaction required the SH2 domain of CSK and phosphorylation of the tyrosine in the N-terminal ITIM of LAIR1)
  • interaction of CSK with LNX1 depends on the C-terminal PDZ ligand of CSK
  • PAG1 recruitment of CSK into lipid rafts is critical to c-Src kinase activity and bone resorption in osteoclasts
  • associates with TRAF6-p62 interacting with receptor activator of NFKB (RANK) distal region and the complex facilitate activation of RANK down stream signal transduction cascades including NFKB
  • IKBKG the regulatory subunit of the IKK complex, is crucial for osteoclastogenesis and interacts with CSK in osteoclast
  • SCIMP binds to the BLNK adaptor protein and also to the inhibitory kinase CSK
  • cooperative roles of C-terminal Src kinase (CSK) binding protein (PAG1) and Caveolin-1 (CAV1) in the mechanism of Src family tyrosine kinase (SFK) inhibition by CSK
  • F11R recruits CSK to the integrin-SRC complex in resting platelets
  • EEF2 is a substrate of CSK and could locate in the nucleus
  • cell & other
    activated by the engagement of its Src homology (SH) 2 domain
    Other myristoylation and the pocket residues regulate CSK, but in a manner very different from that for ABL1
    ubiquitinated by LNX1, suggesting an interdependent regulation of CSK and LNX1
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal cancer (important early event in colorectal cancer pathogenesis)
    Variant & Polymorphism
    Candidate gene
    Therapy target