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FLASH GENE
Symbol CSHL1 contributors: - updated : 22-08-2005
HGNC name chorionic somatomammotropin hormone-like 1
HGNC id 2442
Location 17q23.3-q24.2      Physical location : 61.986.964 - 61.988.618
Synonym symbol(s) CSHP1, CSL, CS-5
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
text interspersed in the same transcriptional orientation with four other related genes
STRUCTURE 1.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see GH@
Physical map
LOC342541 17q24.1 similar to peptidyl-Pro cis trans isomerase ACE 17q23 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 KCNH6 17q24.2 potassium voltage-gated channel, subfamily H (eag-related), member 6 HAN11 17q24.2 WD-repeat protein LOC51204 17q24.2 clone HQ0477 PRO0477p LOC390806 17 similar to Hypothetical protein FLJ14668 MAP3K3 17q24.2 mitogen-activated protein kinase kinase kinase 3 MGC10986 17q24.2 hypothetical protein MGC10986 LYK5 17q24.2 protein kinase LYK5 GK001 17q24.2 GK001 protein DDX42 17q24.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 FTSJ3 17q23 FtsJ homolog 3 (E. coli) PSMC5 17q24-q25 proteasome (prosome, macropain) 26S subunit, ATPase, 5 SMARCD2 17q23-q24 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 LOC388410 17 LOC388410 CSH2 17q23.3-q24.2 chorionic somatomammotropin hormone 2 GH2 17q23 growth hormone 2 CSH1 17q23.3-q24.2 chorionic somatomammotropin hormone 1 (placental lactogen) CSHL1 17q23.3-q24.2 chorionic somatomammotropin hormone-like 1 GH1 17q24 growth hormone 1 CD79B 17q23 CD79B antigen (immunoglobulin-associated beta) SCN4A 17q23 sodium channel, voltage-gated, type IV, alpha ICAM2 17q23-q25 intercellular adhesion molecule 2 ERN1 16p12 ER to nucleus signalling 1 FLJ30999 17q24.2 hypothetical protein FLJ30999 HT008 17q24.2 uncharacterized hypothalamus protein HT008
regionally located located at the growth hormone locus and interspersed in the same transcriptional orientation with four other related genes
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 661 - 18 - Misra-Press,MacLeod
  • missing exon 2
  • utilizing the normal splice acceptor site in exon 3
  • lackings a signal sequence (indicating a non-secreted protein)
  • - splicing 376 - 23 - Misra-Press,MacLeod
  • lacking exons 2,3 and 4
  • missing a signal sequence (predicting a non-secreted protein)
  • - splicing 837 25.4 222 - Misra-Press,MacLeod
  • utilizing a cryptic splice donor site 19 nt into intron B and an alternative splice acceptor site 4 nt into exon 3
  • having six internal residues
  • retaining the signal sequence
  • - splicing 588 16 139 - Misra-Press,MacLeod
  • missing exon 2
  • utilizing an alternate splice acceptor site in exon 3
  • lacking a signal sequence
  • - splicing 768 22.7 199 - Misra-Press,MacLeod
  • utilizing a cryptic splice donor site 19 nt into intron B and an alternative splice acceptor site 73 nt into exon 3
  • having six internal residues
  • retaining the signal sequence
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, chorion, placental villi
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY somatotropin/prolactin family of hormones
    CATEGORY regulatory , signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION playing an important role in growth control
    CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS