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FLASH GENE
Symbol CSF3 contributors: mct - updated : 24-01-2017
HGNC name colony stimulating factor 3 (granulocyte)
HGNC id 2438
Location 17q21.1      Physical location : 38.171.613 - 38.174.065
Synonym name
  • chromosome 17 open reading frame 33
  • filgrastim
  • lenograstim
  • pluripoietin
    • Synonym symbol(s) G-CSF, GCSF, MGC45931, C17orf33, INN
    DNA
    TYPE functioning gene
    STRUCTURE 2.45 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see NF1 NF1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 1518 - 207 - 2015 25721620
  • a 30 aa signal peptide of 3.3 kda
  • a 177 mature peptide of 19 kda
    • 5 splicing 1509 - 204 - 2015 25721620
  • a 30 aa signal peptidez of 3.3 kda
  • a 174 aa mature peptide of 18.7 kda
    • 4 splicing 1703 21.4 200 - 2015 25721620
  • using an alternate in-frame splice site
  • lacking a signal peptide
    • 4 - 1485 - 168 - 2015 25721620
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuteruscervix highly
    Respiratorylung   highly
    Skin/Tegumentskin   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 30 aa signal peptide of 21.4 kda
    • conjugated GlycoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Csf3 (75.9 pc)
    homolog to murine Csf3 (74.3 pc)
    Homologene
    FAMILY
  • IL-6 superfamily
    • CATEGORY signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • inducing PRTN3 (see symbols), JUNB and/or TOP in the proliferative response of human myeloid leukemia
  • colony-stimulating factor 3, playing a pivotal role in growth control of granulocytic progenitors
  • significant contribution of PSMD3-CSF3 and PLCB4 loci to the regulation of neutrophil count
  • possible role of CSF3 in malignant transformation, particularly in patients with neutropenia harboring mutations in the gene encoding the CSF3R
  • could act directly on cardiac mitochondria to prevent mitochondrial dysfunction caused by oxidative stress
  • EPO combined with CSF3 enhanced MMP2 expression in mesenchymal stem cells (MSCs), promoted MSC motility and activated the ERK1/2 signaling pathway
  • KITLG and CSF3 promote neuronal differentiation and inhibit astroglial differentiation at the early stage of differentiation
  • is important in mobilising neutrophils from the bone marrow but also has a range of proinflammatory effects
  • may play an important role in exacerbating disease in antineutrophil cytoplasmic antibody (ANCA) vasculitis
  • might be an important factor in the regeneration and differentiation of the enteric nervous system (ENS) and might be a useful tool for the investigation and treatment of ENS disorders
  • potential role of CSF3 in the progression of intracranial aneurysms
  • promotes autophagy by inhibiting the NFKB1 signal pathway and protects neuronal structure after spinal cord injury
  • should be considered as an additional regulatory factor that contributes to a successful embryo implantation and to the placenta development
  • emerges as a new player in free fatty acids (FFAs)-induced insulin resistance and thus may be of interest as a target for prevention and treatment of type 2 diabetes
  • down-regulates TLR expression via the transcription factor SPI1 in human monocytes
  • is a hematopoietic cytokine that stimulates neutrophil production and hematopoietic stem cell mobilization by initiating the dimerization of homodimeric granulocyte colony-stimulating factor receptor
    • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development , immunity/defense
    text
  • granulocyte differentiation
  • multicellular organismal development
  • positive regulation of cell proliferation
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to IL6R
  • PLG regulates MMP9-dependent CXCR4 expression to facilitate hematopoietic progenitor and stem cell (HPSC) mobilization in response to CSF3
  • downregulates TLR1, TLR2 and TLR4 in a time- and dose-dependent fashion in human monocytes
    • cell & other
    REGULATION
    Other regulated by SPI1,MYB and others
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to severe congenital neutropenia
    Variant & Polymorphism
    Candidate gene
    Marker
  • endogenous CSF3 (enG-CSF) level is a good biomarker for prediction of severity of acute ischemic stroke
    • Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    may be of interest as a target for prevention and treatment of type 2 diabetes
    neurologyacquired 
    provide an effective auxiliary therapeutic intervention for spinal cord injury
    ANIMAL & CELL MODELS
  • Csf3/Csf3r axis is fundamentally important for long-term muscle regeneration, functional maintenance and lifespan extension in mouse models of DMD with varying severities