Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | CSF2RA | contributors: mct - updated : 22-03-2020 |
HGNC name | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) |
HGNC id | 2435 |
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Corresponding disease |
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Location | Xp22.33 Physical location : 1.337.692 - 1.428.828 | ||
Synonym name | |||
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Synonym symbol(s) | GMRX, CSF2R, CD116, GMCSFR, GM-CSF-R-alpha, CSF2RAX, MGC3848, MGC4838, CD116, CDw116, CSF2RX, CSF2RAY, CSF2RY, GMR, SMDP4, alphaGMR |
DNA |
TYPE | functioning gene |
STRUCTURE | 41.12 kb 13 Exon(s) |
text structure | no TATA box, a purine-rich stretch, 30bp upstream initiation site |
MAPPING | cloned | Y | linked | status | provisional |
Map | see IL3RAX |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
expressed in | (based on citations) |
organ(s) |
tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | GlycoP |
mono polymer | heteromer , dimer |
HOMOLOGY |
Homologene |
FAMILY | |
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CATEGORY | receptor membrane |
SUBCELLULAR LOCALIZATION | extracellular |
plasma membrane |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling | signal transduction |
CSF2RA, CSF2RB signaling is required for the development of nonlymphoid tissue-resident Dendritic cells in the steady state and for the induction of CD8+ T cell immunity against particulate antigens |
a component | |
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INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | SMDP4 |
Other morbid association(s) |
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Susceptibility | to SAPHO syndrome, a type of rare chronic aseptic inflammation |
Variant & Polymorphism other | |
Candidate gene | |||||||||||||||
Marker
Therapy target
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ANIMAL & CELL MODELS |