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FLASH GENE
Symbol CSF1 contributors: mct - updated : 21-03-2016
HGNC name colony stimulating factor 1 (macrophage)
HGNC id 2432
Location 1p13.3      Physical location : 110.453.232 - 110.472.354
Synonym name
  • macrophage colony stimulating factor
  • lanimostim
  • Synonym symbol(s) M-CSF, MCSF, MGC31930
    EC.number 2.7.10.1
    DNA
    TYPE functioning gene
    STRUCTURE 19.12 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2973 60.1 554 - 2008 17916748
    9 - 1743 - 438 - 2008 17916748
    9 - 2079 29 256 - 2008 17916748
    9 - 2772 60 554 - 2008 17916748
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselscapillary   
    Digestivestomach   highly
    Reproductivefemale systemuteruscervix highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connectivebone   
    Epithelialbarrier/liningendothelium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     fibroblast
    Lymphoid/Immunemacrophage Homo sapiens
    Skeletonosteoblast Homo sapiens
    Skeletonosteoclast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Habc domain and/or "linker" region
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • cytokine that controls the production, differentiation, and function of macrophages
  • may be involved in development of the placenta
  • regulates the proliferation and survival of cells of the monocyte/macrophage lineage, their differentiation into macrophages, and macrophage activation
  • main growth factor controlling the development of macrophages from myeloid progenitor cells
  • key regulator of STX7 expression and function in macrophages
  • regulates macrophage growth and differentiation and plays a role in atherogenesis
  • tumor-cell produced CSF1 contributes to osteoclast development and survival in bone metastasis
  • CSF1-mediated inhibition of TNFSF11 expression on osteoblasts may provide an important mechanism for coupling bone formation/resorption and preventing excessive osteoclastogenesis during normal skeletal growth
  • plays a unique role in bone remodeling
  • possible local and systemic involvement in humans during fracture healing
  • hematopoietic growth factor that activates microglial cells, involved in phagocytosis of amyloid-beta (Abeta) in the brain
  • regulates macrophage and osteoclast development
  • functional overlap but differential expression of CSF1 and IL34 in their CSF1 receptor-mediated regulation of myeloid cells
  • has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum
  • central role in the coordination of tissue macrophage and dendritic cell homeostasis
  • major physiological regulator of the proliferation, differentiation and survival of cells of the mononuclear phagocyte lineage
  • CSF1 dependent ERK activation and proliferation are regulated differentially in progenitors and differentiated cells
  • CSF1 and CSF2 can regulate the development and function of the mononuclear phagocyte system (MPS)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to a receptor protein-tyrosine kinase and utilizes autophosphorylation to initiate signal transduction
  • interacting with STX7 (increase the binding of STX7 to its SNARE partners by inducing the phosphorylation of serine residues in the Habc domain and/or "linker" region of STX7)
  • MAFB specifically restricts the ability of CSF1 to instruct myeloid commitment divisions in hematopoietic stem cell
  • induces macrophage transformation by upregulating JUN with a certain synergy of NFKB1
  • IL4 pathway of proliferation may have developed as an alternative to CSF1 to increase resident macrophages numbers without coincident monocyte recruitment
  • TBX3 plays an important role in osteoclastogenesis at least in part by regulating CSF1-dependent expression of JDP2
  • sCLU reduces osteoclastogenesis formation by inhibiting the actions of CSF1, thereby suggesting its protective role in bone erosion
  • upregulation of CSF2 and CSF1 production by endothelial cells, an effect that appears to be mediated by NFKB1 and to be independent of IL1, may be an additional mechanism through which IL33 contributes to inflammatory activation of the vessel wall
  • cell & other
    REGULATION
    activated by CRP (CRP up-regulates CSF1 release from monocyte-derived macrophages and aortic endothelial cells and increased macrophage proliferation)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with COL6A3 in translocation t(1;2)(p13;q37) in tenosynovial giant cell tumors
    constitutional     --over  
    in patients with physiological fracture healing
    Susceptibility to Paget disease
    Variant & Polymorphism other rs484959 strongly associated with Paget disease (Albagha 2010)
    Candidate gene
    Marker
  • could be a putative biomarker for mild cognitive impairment (MCI)
  • Therapy target
    SystemTypeDisorderPubmed
    cancermuscle 
    CSF1-targeted therapies in in nongynecological leiomyosarcoma
    ANIMAL & CELL MODELS