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FLASH GENE
Symbol CS contributors: mct - updated : 07-06-2018
HGNC name citrate synthase
HGNC id 2422
Location 12p13.3      Physical location : 56.665.482 - 56.694.175
Synonym name citrate synthase, mitochondrial
EC.number 2.3.3.1
DNA
TYPE functioning gene
STRUCTURE 28.69 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 2997 - 466 - Kullberg (2006), Cheng (2009)
  • also called CSa
  • a putative N-terminal mitochondrial targeting sequence (MTS)
  • - splicing 3080 - 400 - Kullberg (2006), Cheng (2009)
  • also called CSb
  • with a shorter N terminus, lacking the mitochondrial targeting sequence (MTS)
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouth   highly
     salivary gland    
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • citrate synthase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    tricarboxylic acid cycle
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CS is a direct RORA target gene and one mechanism by which RORA regulates lipid metabolism is via regulation of CS expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    In pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS