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FLASH GENE
Symbol CS contributors: mct - updated : 07-06-2018
HGNC name citrate synthase
HGNC id 2422
Location 12p13.3      Physical location : 56.665.482 - 56.694.175
Synonym name citrate synthase, mitochondrial
EC.number 2.3.3.1
DNA
TYPE functioning gene
STRUCTURE 28.69 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
DGKA 12q13.3 diacylglycerol kinase, alpha 80kDa SILV 12q13-q14 silver homolog (mouse) CDK2 12q13.3 cyclin-dependent kinase 2 SUOX RAB5B 12q13 RAB5B, member RAS oncogene family ZNFN1A4 12q13 zinc finger protein, subfamily 1A, 4 (Eos) RPS26 12q14 ribosomal protein S26 ERBB3 12q13.3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) PA2G4 12q13 proliferation-associated 2G4, 38kDa RPL41 12q14 ribosomal protein L41 FLJ14451 12q13.13 hypothetical protein FLJ14451 MBC2 12q13.13 hypothetical protein FLJ14451 MLC1SA 12q13.13 hypothetical protein FLJ14451 MYL6 12q12 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle SMARCC2 12q13-q14 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 RNF41 12q13.13 ring finger protein 41 MGC2731 12q13.13 hypothetical protein MGC2731 SLC39A5 12q13.3 solute carrier family 39 (metal ion transporter), member 5 FLJ34236 12q13.13 hypothetical protein FLJ34236 FLJ32452 12q13.13 hypothetical protein FLJ32452 CS 12p11-qter citrate synthase TMEM4 12q15 transmembrane protein 4 USP52 12q13.2-q13.3 ubiquitin specific protease 52 APOF 12q13.13 apolipoprotein F IL23A 12q13.2-q13.3 interleukin 23, alpha subunit p19 STAT2 17q11.1-q22 signal transducer and activator of transcription 2, 113kDa LOC390331 12 similar to hypothetical protein FLJ10560 TIMELESS 12q12-q13 timeless homolog (Drosophila) MIP 12q13 major intrinsic protein of lens fiber LOC283377 12q13.13 hypothetical protein LOC283377 GA 12q13 hypothetical protein LOC283377 LOC338801 12q13.13 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 2997 - 466 - Kullberg (2006), Cheng (2009)
  • also called CSa
  • a putative N-terminal mitochondrial targeting sequence (MTS)
  • - splicing 3080 - 400 - Kullberg (2006), Cheng (2009)
  • also called CSb
  • with a shorter N terminus, lacking the mitochondrial targeting sequence (MTS)
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouth   highly
     salivary gland    
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • citrate synthase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    tricarboxylic acid cycle
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CS is a direct RORA target gene and one mechanism by which RORA regulates lipid metabolism is via regulation of CS expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    In pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS