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FLASH GENE
Symbol CRYZL1 contributors: - updated : 03-11-2006
HGNC name crystallin, zeta (quinone reductase)-like 1
HGNC id 2420
Location 21q21.3      Physical location : 34.961.649 - 35.014.160
Synonym name
  • quinone reductase-like 1
    • Synonym symbol(s) 4P11, QOH-1
    EC.number 1.-.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 52.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure rare AT-AC splice site
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivepharynx   predominantly
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunethymus   moderately
    Nervousbrain    
    Reproductivemale systemprostate  highly
     male systemtestis  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved NAD(P)H binding site
    • HOMOLOGY
    interspecies homolog to murine Cryzl1 (90.8 pc)
    homolog to rattus Cryzl1 (89.4 pc)
    homolog to chicken CRYZL1 (79.1 pc)
    Homologene
    FAMILY
  • zinc-containing alcohol dehydrogenase family
  • quinone oxidoreductase subfamily
    • CATEGORY enzyme , structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • having an NADPH : quinone oxidoreductase activity
  • contributing to the refractive index and transparency of lens
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS