Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | CRX | contributors: mct/npt - updated : 06-04-2016 |
HGNC name | cone-rod homeobox |
HGNC id | 2383 |
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Corresponding disease |
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Location | 19q13.32 Physical location : 48.325.098 - 48.346.584 | ||||
Synonym name | |||||
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Synonym symbol(s) | RHDP3, OTX, CRD,, OTX3 |
DNA |
TYPE | functioning gene |
STRUCTURE | 21.49 kb 4 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter |
Binding site | |
text structure | OTX/CRX and SP1/AP2 binding sites |
MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
physiological period | fetal |
Text | eye, choroid, lens, retina, anterior segment |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | homolog to Drosophila orthodenticle (Otx) |
homolog to murine crx |
Homologene |
FAMILY |
CATEGORY | DNA associated , transcription factor |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,nucleus |
basic FUNCTION | |
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CELLULAR PROCESS | nucleotide, transcription |
PHYSIOLOGICAL PROCESS | development |
text | involved in the developemment of cntral nervous system and eye |
PATHWAY |
metabolism |
signaling | sensory transduction/vision |
a component |
INTERACTION |
DNA | binding to the locus control region of the cone pigment cluster LCR-RGCP@ |
RNA |
small molecule |
cell & other |
REGULATION |
activated by | TH (Liu 2007) |
ASSOCIATED DISORDERS |
corresponding disease(s) | CORD2 , LCA7 |
related resource | Retinal Information Network |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |