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FLASH GENE
Symbol CRTC3 contributors: mct - updated : 08-01-2018
HGNC name CREB regulated transcription coactivator 3
HGNC id 26148
Location 15q26.1      Physical location : 91.073.197 - 91.188.576
Synonym name transducer of regulated cAMP response element-binding protein (CREB)3
Synonym symbol(s) FLJ21868, TORC3, TORC-3
DNA
TYPE functioning gene
STRUCTURE 115.38 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 5171 - 619 - 2012 23033494
15 - 5168 - 618 - 2012 23033494
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemuteruscervix highly
 female systemplacenta  highly
Respiratoryrespiratory tracttrachea  highly
Visualeyeretina   
 eyeanterior segment   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadiposebrown   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
not specificadipocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY Transducers of Regulated CREB activity family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • play a key role in linking these external signals to the transcriptional program of adaptive mitochondrial biogenesis by activating PGC-1alpha gene transcription
  • promotes obesity by attenuating ADRB signalling in adipose tissue
  • promotes obesity by attenuating ADRB signalling in adipose tissue
  • contributes to the development of insulin resistance and type II diabetes
  • plays a selective role in mitochondrial biogenesis in response to rotenone (
  • plays important roles in glucose and energy metabolism
  • in skeletal muscle, CRTC3 affects lipid and glycogen metabolism and mitochondrial biogenesis
  • CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • the ankyrin repeat domain of BCL3 interacted with TORC3
  • key role for the SIK1-CRTC3 signaling axis in the immune system
  • beta-agonists or catecholamines released during intense exercise induce CREB-mediated transcriptional programs through activation of its obligate coactivators CRTC2 and CRTC3
  • SIK2 increases SLC2A4 levels, regulates CRTC2, CRTC3, HDAC4 and glucose uptake in adipocytes
  • STK11 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
  • cell & other
    REGULATION
    activated by in response to catecholamine signals, when it reduced adenyl cyclase activity by upregulating the expression of RGS2, a GTPase-activating protein that also inhibits adenyl cyclase activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with MAML2, in mucoepidermoid carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CRTC1/3-MAML2 fusion gene analysis can be a useful method for diagnosing hidradenoma
  • higher serum CRTC3 concentrations are related to and predict a poorer metabolic profile in children
  • Therapy target
    ANIMAL & CELL MODELS