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FLASH GENE
Symbol CRTC1 contributors: mct/ - updated : 28-06-2017
HGNC name CREB regulated transcription coactivator 1
HGNC id 16062
Location 19p13.11      Physical location : 18.794.424 - 18.893.142
Synonym name
  • transducer of regulated cAMP response element-binding protein (CREB) 1
  • mucoepidermoid carcinoma translocated 1
  • transducer of CREB protein 1
  • CREB-regulated transcription coactivator 1
  • Synonym symbol(s) TORC1, WAMTP1, FLJ14027, KIAA0616, MECT1, TOR2
    DNA
    TYPE functioning gene
    STRUCTURE 98.72 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 6961 - 634 - 2004 14720503
    15 - 7009 - 650 - 2004 14720503
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine    
    Nervousbrain   highly Homo sapiens
     nerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal coiled-coil domain
  • a protein kinase A phosphorylation site
  • a formin homology 1 (FH1) domain
  • a formin homology 2 (FH2) domain
  • an activation domain responsive to MAP3K1 stimulation mapped to AAS 431-650
  • HOMOLOGY
    Homologene
    FAMILY
  • formin homology family
  • cappuccino subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text locate primarily in the cytoplasm but have also been reported to shuttle into the nucleus
    basic FUNCTION
  • involved in regulation of transcription, DNA-dependent
  • controls cell growth via a rapamycin-sensitive signaling branch regulating translation, transcription, nutrient uptake, ribosome biogenesis, and autophagy
  • required for energy balance and fertility, and probably may also promote the development of obesity
  • potent and indispensable modulator of AP-1 function (a potent, modulator of AP-1 activity that associates with c-Jun and c-Fos and promotes c-Jun–mediated cellular proliferation and transformation)
  • major cell growth regulator
  • with CRTC2, contribute to the regulation of Na(+) absorption
  • central kinase that coordinates nutrient availability with eukaryotic cell growth
  • CRTC1- signaling is coupled to heat-induced SGs (stress granules) to protect cells from DNA damage
  • key role for salt inducible kinase 1 (SIK1) and CREB-regulated transcription coactivator 1 (CRTC1) in clock re-setting
  • critical role of CRTC1-dependent transcription on spatial memory formation, providing the first evidence that targeting brain transcriptome reverses memory loss in Alzheimer
  • nuclear CRTC1 can bind to CREB possibly altering transcription during epileptogenesis
  • is a master regulator of metabolism in eukaryotes that responds to multiple upstream signaling pathways
  • confers broad spectrum protection against hepatic steatosis development
  • transcription cofactor CRTC1 is a critical determinant of sustained gene transcription and memory strength in the hippocampus
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    CREB1-CRTC1 pathway mediates the central effects of hormones and nutrients on energy balance and fertility
    a component
  • de-regulated STK11-CRTC1 signaling might represent a crucial mechanism for esophageal cancer progression
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL8 activator
  • bound CREB1 (to regulate CARTPT and KISS1 gene expression through a direct mechanism)
  • interacting with MAP3K1 (new mechanism for regulated activation of CRTC1 transcriptional coactivator and CREB signaling)
  • interacting with PIN1
  • SIK2 plays critical roles in neuronal survival, is modulated by CaMKI/IV, and regulates CREB1 via CRTC1
  • RAB5A controls CRTC1 activation and localization in mammalian cells
  • specifically uncouples AMPK/calcineurin-mediated effects on lifespan from pleiotropic side effects by reprogramming mitochondrial and metabolic function
  • WDR24 has both CRTC1 dependent and independent functions in the regulation of cellular metabolism
  • CRTC1 directly interferes with the expression of genes regulated by lipogenic transcription factors, most prominently liver x receptor alpha (NR1H3)
  • following associative learning, synaptically localized CRTC1 is translocated to the nucleus and regulates FGF1 transcription in an activity-dependent manner
  • cell & other
    REGULATION
    activated by hormonal and nutrient signals in the hypothalamus, where it promotes energy balance and fertility by enhancing CREB1 activity over relevant genes
    Other regulation of CRTC1 is an essential part of both nutrient and growth factor signaling
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fused with MAML2 in t(11:19)(q21;p13) in mucoepidermoid salivary gland carcinoma and in clear cell hidradenoma of the skin, and benign Warthin's tumors, with a significantly lower risk of local recurrence, metastases, or tumor-related death
    constitutional       gain of function
    brain malformations in Tuberous sclerosis complex (TSC) are likely a consequence of increased CRTC1 activation during embryonic brain development
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CRTC1/3-MAML2 fusion gene analysis can be a useful method for diagnosing hidradenoma
  • detection of the CRTC1/MAML2 fusion transcript provides useful information for mucoepidermoid carcinoma (MEC) diagnosis but is not associated with differences in survival outcomes
  • Therapy target
    SystemTypeDisorderPubmed
    miscelleaneoushypertension 
    pharmacological manipulation of CRTC1/2 signalling may provide novel therapies for Na(+)-sensitive hypertension
    ANIMAL & CELL MODELS