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FLASH GENE
Symbol CRTAM contributors: KTN - updated : 31-07-2008
HGNC name cytotoxic and regulatory T cell molecule
HGNC id 24313
Location 11q24.1      Physical location : 122.709.254 - 122.743.345
Synonym name class-I MHC-restricted T cell associated molecule
DNA
TYPE functioning gene
STRUCTURE 34.10 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC255849 11q24.1 hypothetical LOC255849 LOC390257 11 similar to Glutamine synthetase (Glutamate--ammonia ligase) LOC390258 11 similar to scaffold attachment factor B; heat-shock protein (HSP27) estrogen response element and TATA box-binding protein; HSP27 ERE-TATA-binding protein; glutathione S-transferase fusion protein; scaffold attachment factor B1 KIAA1959 11q24.1 nm23-phosphorylated unknown substrate CRTAM 11q22-q23 class-I MHC-restricted T cell associated molecule FLJ23554 11q24.1 hypothetical protein FLJ23554 LOC390259 11 similar to brain-specific homeodomain protein LOC341056 11q24.1 similar to SUMO-1 activating enzyme subunit 1; SUMO-1 activating enzyme E1 N subunit; sentrin/SUMO-activating protein AOS1; ubiquitin-like protein SUMO-1 activating enzyme HSPA8 11q23.3-q25 heat shock 70kDa protein 8 LOC85391 11q23.3-q25 RNA, small nucleolar ASAM 11q24.1 adipocyte-specific adhesion molecule LOC283157 11q24.1 similar to RIKEN cDNA A930008A22 KIAA1201 11q24.1 KIAA1201 protein SCN3B 11q23.3 sodium channel, voltage-gated, type III, beta ZNF202 11q23.3 zinc finger protein 202 LOC390260 11 similar to Olfactory receptor 6X1 LOC390261 11 similar to Olfactory receptor 6M1 LOC390262 11 similar to Olfactory receptor 6M1 LOC390263 11 similar to Olfactory receptor 6M1 LOC338661 11q24.1 hypothetical LOC338661
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2422 44.5 393 - -
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   moderately
Nervousbrain   highly
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal moderately
cell lineage
cell lines
fluid/secretion predominantly in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 17 aa signal peptide
  • an Ig-like (immunoglobulin-like) V-type domaine
  • an Ig-like (immunoglobulin-like)C2-type domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Crtam (71.7 pc)
    homolog to murine Crtam (72.5 pc)
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • iglon family
  • nectin family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • attached to the membrane by a GPI-anchor
  • single-pass type I membrane protein
  • basic FUNCTION
  • mediating selective neuronal growth and axon targeting
  • contributing to the guidance of developing axons and remodeling of mature circuits in the limbic system
  • involved in positive regulation of cytokine secretion
  • involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CADM1 (could regulate a large panel of cell/cell interactions both within and outside of the immune system)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS