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FLASH GENE

Symbol

CRTAC1

contributors: npt/mct - updated : 19-09-2012

HGNC name	cartilage acidic protein 1
HGNC id	14882

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q24.2      Physical location : 99.624.757 - 99.790.585
Synonym name	chondrocyte expressed protein 68 kDa CEP-68
	acidic secreted protein in cartilage
	lateral olfactory tract usher substance (LOTUS)
Synonym symbol(s)	CEP-68, ASPIC1, FLJ10320, ASPIC, LOTUS

DNA

TYPE	functioning gene
STRUCTURE	165.83 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	alternate last exon usage

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018058 15 - 2912 NP_060528 - 661 produced by chondrocytes and localizes in the extracellular matrix of articular cartilage 2011 21817055 variant 1 or CRTAC1A an exon sharing process with the neighbouring tail-to-tail orientated gene leading to CRTAC1A NM_001206528 15 - 2361 NP_001193457 - 645 specifically expressed in brain tissue 2011 21817055 CRTAC1B key molecule for lateral olfactory tract (LOT) formation and named LOT usher substance (LOTUS) binds to RTN4R and functions as an endogenous RTN4R antagonist membrane protein

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Respiratory lung         Urinary kidney       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Connective cartilage

cells

System Cell Pubmed Species Stage Rna symbol   chondrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal leader peptide
	hydrophobic AA sequences corresponding to a primary transmembrane helix of 627 to 646 AAs
	four phenylalanyl–glycyl and glycyl–alanyl–prolyl (FG-GAP) domains
	C terminal EGF-like calcium-binding domain encoding sequence, (UA/EC domain) bound to RTN4R, and blocks the binding of RTN4 to RTN4R

HOMOLOGY

Homologene

FAMILY

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix

basic FUNCTION	glycosylated extracellular matrix molecule of articular cartilage
	functions in lateral olfactory tract development through an antagonism to RTN4R

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binds to RTN4R and functions as an endogenous RTN4R antagonist

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology acquired   UA/EC domain may be useful for therapeutic approaches in injured or degenerative brains

ANIMAL & CELL MODELS