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FLASH GENE
Symbol CROT contributors: npt/mct - updated : 21/11/2008
HGNC name carnitine O-octanoyltransferase
HGNC id 2366
Location 7q21.1      Physical location : 86.974.950 - 87.029.115
Synonym name
  • rat peroxisomal carnitine octanoyltransferase-like 1
  • peroxisomal carnitine O-octanoyltransferase
  • Synonym symbol(s) COTL1, COT
    EC.number 2.3.1.137
    DNA
    TYPE functioning gene
    STRUCTURE 54.09 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see SRI
    Physical map
    SEMA3A 2q37-qter sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A HMG17P1 7q11-q21 high-mobility group (nonhistone chromosomal) protein 17 pseudogene 1 LOC285984 7q21.12 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) SEMA3D 7q21.12 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D LOC392067 7 similar to dynein, cytoplasmic, light peptide GRM3 7q21.1-q21.2 glutamate receptor, metabotropic 3 FLJ31340 7q21.13 hypothetical protein FLJ31340 DMTF1 7q21.1 cyclin D binding myb-like transcription factor 1 C7orf23 7q21.1-q21.2 chromosome 7 open reading frame 23 TP53AP1 7q21.1 TP53 activated protein 1 CROT 7q21.1 carnitine O-octanoyltransferase ABCB4 7q21.1 ATP-binding cassette, sub-family B (MDR/TAP), member 4 ABCB1 7q21.1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 RPIB9 7q21.13 Rap2-binding protein 9 MCFP 7q21.13 mitochondrial carrier family protein ASK 7q21.3 mitochondrial carrier family protein ADAM22 7q21.1 a disintegrin and metalloproteinase domain 22 SRI 7q21.1 sorcin FLJ23153 7q21.13 likely ortholog of mouse tumor necrosis-alpha-induced adipose-related protein LOC392068 7 similar to CSRP2 binding protein isoform a; CRP2 binding protein; cysteine rich protein 2 binding protein; CRP2 binding partner LOC392069 7 similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) LOC219558 7q21.13 similar to elongation factor 1 alpha FLJ32110 7q21.13-q21.2 hypothetical protein FLJ32110 MGC26647 7q21.13 hypothetical protein MGC26647 STEAP 7q21 six transmembrane epithelial antigen of the prostate STEAP2 7q21 six transmembrane epithelial antigen of prostate 2 FLJ21062 7q21.2 hypothetical protein FLJ21062 LOC85865 7q21.2 hypothetical protein BC004923 CLDN12 7q21 claudin 12
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3211 70 612 - Morillas (2002)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Nervousnerve   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • malonyl-CoA domain that might be the site at which malonyl-CoA interacts with the substrate acyl-CoA
  • HOMOLOGY
    Homologene
    FAMILY
  • carnitine/choline acetyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • catalyzes the reversible transfer of fatty acyl groups between CoA and carnitine, crucial step in the transport of medium- and long-chain acyl-CoA out of the mammalian peroxisome to the cytosol and mitochondria
  • CELLULAR PROCESS cell cycle, checkpoint
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text
  • beta-oxydation of branched chain, fatty acids, C6 to C2, negative regulation
  • PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by malonyl-CoA
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS