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FLASH GENE
Symbol CROT contributors: npt/mct - updated : 21/11/2008
HGNC name carnitine O-octanoyltransferase
HGNC id 2366
Location 7q21.1      Physical location : 86.974.950 - 87.029.115
Synonym name
  • rat peroxisomal carnitine octanoyltransferase-like 1
  • peroxisomal carnitine O-octanoyltransferase
    • Synonym symbol(s) COTL1, COT
    EC.number 2.3.1.137
    DNA
    TYPE functioning gene
    STRUCTURE 54.09 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see SRI
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3211 70 612 - Morillas (2002)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Nervousnerve   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • malonyl-CoA domain that might be the site at which malonyl-CoA interacts with the substrate acyl-CoA
    • HOMOLOGY
    Homologene
    FAMILY
  • carnitine/choline acetyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • catalyzes the reversible transfer of fatty acyl groups between CoA and carnitine, crucial step in the transport of medium- and long-chain acyl-CoA out of the mammalian peroxisome to the cytosol and mitochondria
    • CELLULAR PROCESS cell cycle, checkpoint
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text
  • beta-oxydation of branched chain, fatty acids, C6 to C2, negative regulation
    • PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by malonyl-CoA
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS