Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CRMP1 contributors: mct/npt - updated : 04-09-2018
HGNC name collapsin response mediator protein 1
HGNC id 2365
Location 4p16.1-p15      Physical location : 5.822.491 - 5.894.785
Synonym name
  • dihydropyrimidinase-like 1
  • dihydropyrimidinase related protein-1
    • Synonym symbol(s) DHPRP1, DPYSL1, DRP1, CRMP-1
    EC.number 3.5.4.2
    DNA
    TYPE functioning gene
    STRUCTURE 72.29 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3046 62.2 572 - Leung, Weidemann (2006)
    - - 6408 150.9 1388 - Leung
    14 - 3155 - 686 - Weidemann (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Nervousbrain   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, neonatal
    Text
  • brain, developing limb, ectoderm
  • abundant in neuronal progenitors of the subependymal layer and in differentiating interneurons
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an amidohydrolase motif
    • mono polymer heteromer , polymer
    HOMOLOGY
    interspecies homolog to C.elegans unc-33
    intraspecies homolog to dihydropyrimidinase protein 1
    Homologene
    FAMILY
  • amidohydrolase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • putatively involved in pyrimidine catabolism
  • neural growth cone collapse
  • suppressor of metastastic invasion
  • involved in invasion, and aggressiveness of prolactin pituitary tumors (Wierinckx 2007)
  • CRMP1 and DPYSL3 regulate likely proper orientation of the basal dendrites of layer V neurons in the cerebral cortex
    • CELLULAR PROCESS nucleotide, chromatin organization
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
  • complexing with dihydropyriminidase (DPYSLs)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p80-ROK-alpha associating with PPYSL2 and modulating RhoA-induced neuronal morphogenesis
  • interacting with GNE and ZBTB16
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS