Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CRMP1 contributors: mct/npt - updated : 04-09-2018
HGNC name collapsin response mediator protein 1
HGNC id 2365
Location 4p16.1-p15      Physical location : 5.822.491 - 5.894.785
Synonym name
  • dihydropyrimidinase-like 1
  • dihydropyrimidinase related protein-1
  • Synonym symbol(s) DHPRP1, DPYSL1, DRP1, CRMP-1
    EC.number 3.5.4.2
    DNA
    TYPE functioning gene
    STRUCTURE 72.29 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    OTOP1 4p16.2 otopetrin 1 MGC13159 4p16.2 hypothetical protein MGC13159 LYAR 4p16.2 hypothetical protein FLJ20425 ZNF509 4p16.2 zinc finger protein 509 D4S234E 4p16.3 DNA segment on chromosome 4 (unique) 234 expressed sequence STX18 4p16.2 syntaxin 18 MSX1 4p16.3-p16.1 msh homeo box homolog 1 (Drosophila) LDHAL1 4p16.3-p15.3 lactate dehydrogenase A-like 1 LOC132870 4p16.2 hypothetical gene LOC132870 C17 4p16-p15 hypothetical gene LOC132870 HSA250839 4p16.2 gene for serine/threonine protein kinase C4orf6 4p16 chromosome 4 open reading frame 6 EVC2 4p16.2-p16.1 Ellis van Creveld syndrome 2 (limbin) EVC 4p16 Ellis van Creveld syndrome CRMP1 4p16.1-p15 collapsin response mediator protein 1 LOC389197 4 hypothetical gene supported by BX648674 FLJ31564 LOC389198 4 LOC389198 WFS1 4p16.1 Wolfram syndrome 1 (wolframin) PPP2R2C 4p16.1 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform KIAA0935 4p16.1 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform PGR1 4p16.1 T-cell activation protein LOC93622 4p16.1 hypothetical protein BC006130 S100P 4p16 S100 calcium binding protein P MGC9651 4p16.1 hypothetical protein MGC9651 CNO 4p16.1 cappuccino KIAA0232 4p16.1 KIAA0232 gene product KIAA1322 FLJ90575 4p16.1 hypothetical protein FLJ90575 MGC21874 4p16.1 transcriptional adaptor 2 (ADA2 homolog, yeast)-beta GRPEL1 4p16 GrpE-like 1, mitochondrial (E. coli) SORCS2 4p16 GrpE-like 1, mitochondrial (E. coli)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3046 62.2 572 - Leung, Weidemann (2006)
    - - 6408 150.9 1388 - Leung
    14 - 3155 - 686 - Weidemann (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Nervousbrain   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, neonatal
    Text
  • brain, developing limb, ectoderm
  • abundant in neuronal progenitors of the subependymal layer and in differentiating interneurons
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an amidohydrolase motif
  • mono polymer heteromer , polymer
    HOMOLOGY
    interspecies homolog to C.elegans unc-33
    intraspecies homolog to dihydropyrimidinase protein 1
    Homologene
    FAMILY
  • amidohydrolase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • putatively involved in pyrimidine catabolism
  • neural growth cone collapse
  • suppressor of metastastic invasion
  • involved in invasion, and aggressiveness of prolactin pituitary tumors (Wierinckx 2007)
  • CRMP1 and DPYSL3 regulate likely proper orientation of the basal dendrites of layer V neurons in the cerebral cortex
  • CELLULAR PROCESS nucleotide, chromatin organization
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
  • complexing with dihydropyriminidase (DPYSLs)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p80-ROK-alpha associating with PPYSL2 and modulating RhoA-induced neuronal morphogenesis
  • interacting with GNE and ZBTB16
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS